银杏二萜内酯联合水蛭胶囊辅助治疗糖尿病肾病临床观察

发布时间：2018-04-19 01:14

本文选题：糖尿病肾病 + 银杏二萜内酯　；参考：《山东医药》2017年28期

【摘要】：目的探讨银杏二萜内酯联合水蛭胶囊辅助治疗糖尿病肾病(DN)的临床效果及安全性。方法将80例DN患者随机分为观察组和对照组,每组40例。两组均予西医常规治疗,观察组在此基础上予银杏二萜内酯葡胺注射液配合水蛭胶囊辅助治疗。治疗4周,评价两组临床疗效。治疗前及治疗4周,检测两组24 h尿蛋白、β2微球蛋白(β2-MG)、肌酐清除率(Ccr)、血尿素氮(BUN)、血肌酐(Scr)、糖化血红蛋白(HbA1c)、空腹血糖(FPG)、TC、TG、LDL-C等指标,并对治疗前后中医症状积分进行评价。比较治疗期间两组不良反应发生情况。结果观察组临床总有效率明显高于对照组(P0.05)。两组治疗4周肾功能、血脂、血糖等指标较治疗前均有不同程度改善,以观察组改善更明显(P均0.05)。观察组治疗4周中医症状积分较治疗前明显降低,且明显低于对照组治疗4周(P均0.05);对照组治疗前后中医症状积分变化不明显(P0.05)。治疗期间,两组均未出现严重不良反应。结论银杏二萜内酯联合水蛭胶囊辅助治疗DN临床效果较好,且未增加不良反应。
[Abstract]:Objective to investigate the clinical efficacy and safety of ginkgo diterpene lactone combined with leech capsule in the treatment of diabetic nephropathy.Methods 80 patients with DN were randomly divided into observation group and control group with 40 cases in each group.Both groups were treated with routine western medicine, and the observation group was treated with Ginkgo biloba diterpene lactone meglumine injection and Hirudo capsule.After 4 weeks of treatment, the clinical efficacy of the two groups was evaluated.24 h urine protein, 尾 2 microglobulin (尾 2 MGN), creatinine clearance rate (CCR), blood urea nitrogen bun (BUNA), serum creatinine creatinine (SCR), HbA1cn, fasting blood glucose (FBG) and TCGLDL-C were measured before and after treatment in both groups, and the scores of TCM symptoms before and after treatment were evaluated.To compare the occurrence of adverse reactions between the two groups during treatment.Results the total effective rate in the observation group was significantly higher than that in the control group (P 0.05).The indexes of renal function, blood lipid and blood sugar in the two groups were improved in different degree after 4 weeks of treatment, especially in the observation group (P < 0.05).The scores of TCM symptoms in the observation group were significantly lower than those in the control group at 4 weeks after treatment, and were significantly lower than those in the control group at 4 weeks after treatment (P < 0.05), while in the control group there was no significant change in the score of TCM symptoms before and after treatment.During the treatment, there were no serious adverse reactions in both groups.Conclusion Ginkgo biloba diterpene lactone combined with Hirudo capsule is effective in the treatment of DN.
【作者单位】：德州市人民医院;山东省中医药研究院;
【基金】：山东中医药科技发展计划(2011-155、2013-121)
【分类号】：R587.2;R692.9

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