他达拉非联合坦索罗辛治疗FPKRP术后继发阴茎勃起功能障碍的临床观察

发布时间：2018-04-19 04:06

本文选题：他达拉非 + 坦索罗辛　；参考：《中国药房》2017年21期

【摘要】：目的:观察他达拉非联合坦索罗辛治疗经尿道四区分割法双极等离子体前列腺剜切术(FPKRP)后继发阴茎勃起功能障碍(ED)的疗效和安全性。方法:70例FPKRP术后继发ED患者随机分为对照组和观察组,每组35例。两组患者均行常规FPKRP术治疗,术后1 d对照组患者给予盐酸坦索罗辛缓释胶囊0.2 mg,口服,每天1次;观察组患者在对照组治疗基础上加服他达拉非片10 mg,每天1次。两组疗程均为3个月。观察并比较两组患者临床疗效,治疗前后国际前列腺症状评分、前列腺特异抗原、最大尿流率、国际勃起功能问卷-5评分、生活质量指数评分和不良反应发生情况。结果:观察组患者总有效率显著高于对照组,差异有统计学意义(97.14%vs.71.43%,P0.05)。治疗前,两组患者国际前列腺症状评分、最大尿流率、国际勃起功能问卷-5评分和生活质量指数评分比较,差异均无统计学意义(P0.05);治疗后,两组患者国际前列腺症状评分和生活质量指数评分显著低于同组治疗前,且观察组显著低于对照组;最大尿流率和国际勃起功能问卷-5评分显著高于同组治疗前,且观察组显著高于对照组,差异均有统计学意义(P0.05)。两组患者治疗前后前列腺特异抗原水平比较,差异无统计学意义(P0.05)。两组患者不良反应发生率比较,差异无统计学意义(P0.05)。结论:他达拉非联合坦索罗辛治疗FPKRP术后继发ED疗效较好,可有效改善患者阴茎勃起功能,缓解下尿路症状,提高日常生活质量,安全性亦较好。
[Abstract]:Objective: to observe the efficacy and safety of tadalafil combined with tamsoloxine in the treatment of secondary penile erectile dysfunction (EDD) after transurethral four-zone segmenting bipolar plasma enucleation of prostate (FPKRP).Methods 70 patients with secondary Ed after FPKRP were randomly divided into control group and observation group with 35 cases in each group.The patients in both groups were treated with routine FPKRP. The patients in the control group were treated with tansoloxine hydrochloride sustained release capsule (0.2 mg) once a day on the first day, and the patients in the observation group were treated with tacalafil 10 mg per day on the basis of the treatment in the control group.The course of treatment was 3 months in both groups.The clinical efficacy, international prostate symptom score, prostate specific antigen, maximum urinary flow rate, international erectile function questionnaire -5, quality of life index and adverse reactions were observed and compared between the two groups.Results: the total effective rate in the observation group was significantly higher than that in the control group, and the difference was statistically significant (97.14 vs 71.43).Before treatment, there was no significant difference between the two groups in the scores of international prostatic symptoms, maximal urinary flow rate, international erectile function questionnaire -5 score and quality of life index (QQI), but there was no significant difference between the two groups after treatment.The scores of international prostate symptom and quality of life index in both groups were significantly lower than those before treatment in the same group, and those in the observation group were significantly lower than those in the control group, and the scores of maximal urinary flow rate and international erectile function questionnaire -5 were significantly higher than those in the same group before treatment.The observation group was significantly higher than the control group, the difference was statistically significant (P 0.05).There was no significant difference in prostate specific antigen levels between the two groups before and after treatment (P 0.05).There was no significant difference in the incidence of adverse reactions between the two groups (P 0.05).Conclusion: tadalafil combined with tamsoloxine is effective in the treatment of secondary Ed after FPKRP. It can effectively improve the penile erectile function alleviate the symptoms of lower urinary tract improve the quality of daily life and improve the safety.
【作者单位】：儋州市第一人民医院泌尿外科;海南省人民医院泌尿外科;
【分类号】：R698;R699.8

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