尿毒症患者首次血液透析前后抑郁评估及相关因素分析

发布时间：2018-04-19 06:49

本文选题：尿毒症 + 血液透析　；参考：《重庆医学》2018年08期

【摘要】：目的探讨尿毒症患者首次血液透析前后抑郁的状况及其影响因素。方法应用汉密尔顿抑郁量表和自制一般资料调查表对177例尿毒症患者进行问卷调查,同时检测患者实验室指标并进行分析。结果透析前1周35.0%的患者有不同程度抑郁症状,透析后1周11.9%的患者有抑郁症状;透析前后抑郁评分分别为(14.96±8.37)、(6.52±3.81)分,差异有统计学意义(t=16.267,P0.01)。有合并症与无合并症患者抑郁评分,差异有统计学意义(t=-2.528,P=0.013);而患者不同性别、年龄、文化程度、原发病种类,是否吸烟、饮酒的抑郁评分差异无统计学意义(P0.05)。3组研究对象血肌酐(Cr)、血尿素氮(BUN)、空腹血糖(GLU)、清蛋白(Alb)、总胆固醇(TC)水平,差异有统计学意义(P0.01)。Spearman相关分析显示,GLU、Cr、BUN的水平与抑郁评分呈正相关,TC、Alb水平与抑郁评分呈负相关,差异有统计学意义(P0.01)。结论应重视对血液透析患者抑郁状况的评估。
[Abstract]:Objective to investigate the depression status and its influencing factors in uremic patients before and after first hemodialysis.Methods 177 uremic patients were investigated with Hamilton Depression scale and self-made general information questionnaire.Results one week before dialysis, 35.0% of the patients had different degree of depressive symptoms, and 11.9% of the patients had depressive symptoms one week after dialysis, and the scores of depression before and after dialysis were 14.96 卤8.37 and 6.52 卤3.81, respectively, and the difference was statistically significant (P 0.01).There was significant difference in depression score between patients with and without complications, and the difference was statistically significant, and the patients had different sex, age, education, type of primary disease, smoking or not.There was no significant difference in depression score between drinking and drinking. The serum creatinine (Cr), blood urea nitrogen (bun), fasting blood glucose (GLU), serum albumin (Albn), total cholesterol (TC) levels in the subjects of the study group were not significantly different.The difference was statistically significant (P 0.01). Spearman correlation analysis showed that the level of GLU Cr bun was positively correlated with the depression score and the level of TCU Alb was negatively correlated with the depression score, and the difference was statistically significant (P 0.01).Conclusion the evaluation of depression in hemodialysis patients should be emphasized.
【作者单位】：重庆医科大学附属第二医院神经内科;重庆医科大学解剖教研室;
【基金】：重庆市卫生局医学科研项目(2012-1-038) 重庆市教委科学技术研究项目(KJ120314)
【分类号】：R692.5

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