肾脏转运器（LifePort）在心脏死亡器官捐献（DCD）供移植中的应用

发布时间：2018-04-19 17:48

本文选题：LifePort肾脏转运器 + 移植肾功能延迟恢复　；参考：《吉林大学》2014年硕士论文

【摘要】：目的：讨论LifePort在DCD供肾肾移植中应用的有效性，总结LifePort的使用经验。方法：吉林大学第一医院2012年8月至2013年6月实施DCD13例（共26个DCD供肾移植），每例DCD供者的一个肾脏随机采用传统冰桶冷藏保存，共13例（传统冰桶组）；另一个肾脏使用LifePort低温机器灌注保存，共13例（LifePort组）。对比分析二组在肾移植术后的早期移植效果。结果：26个DCD供肾移植手术均获得成功，，术后发生DGF4例，发生率（15.3%，4/26），其中LifePort组1例（7.6%，1/13），传统冰桶组3例（23.0%，3/13），LifePort组DGF发生率显著低于传统冰桶组（p0.05），4例发生DGF受者移植肾功能在术后20~45天恢复正常。未发生DGF的病例资料，术后第7天的平均血清肌酐（Scr）值，其中LifePort组93.61±25.05umol/L，传统冰桶组106.79±34.27umol/L，两组比较无显著差异（P0.05）；LifePort组移植肾血清肌酐恢复正常平均时间5.39±0.97天，传统冰桶组移植肾血清肌酐恢复正常平均时间15.38±3.9天，两组比较差异具有显著性（p0.05）。围手术期发生急性排斥反应2例，发生率（7.6%，2/26）其中LifePort组1例（7.6%，1/13），传统冰桶组1例（7.60%，1/13），两组急性排斥反应发生率比较无显著性差异（P0.05），经治疗后均逆转。结论：应用LifePort保存DCD供肾能缩短移植肾脏功能恢复的时间，可以显著降低肾移植后DGF的发生率。应用LifePort保存DCD供肾安全可靠。
[Abstract]:Objective: to discuss the effectiveness of LifePort in DCD donor kidney transplantation and summarize the experience of LifePort.Methods: DCD13 was performed in the first Hospital of Jilin University from August 2012 to June 2013 (26 cases of DCD donor kidney transplantation). One kidney of each DCD donor was stored in a traditional ice bucket at random.A total of 13 cases (traditional ice bucket group) and another kidney (13 cases of LifePort group) were perfused with LifePort cryogenic machine.The effects of early transplantation after renal transplantation in two groups were compared and analyzed.Results: all 26 DCD donor kidney transplantation operations were successful, and DGF4 occurred in all cases.The incidence of DGF in the LifePort group was significantly lower than that in the conventional ice bucket group. The incidence of DGF in the traditional ice bucket group was significantly lower than that in the conventional ice bucket group. The incidence of DGF in the traditional ice bucket group was significantly lower than that in the conventional ice bucket group. The renal graft function of 4 DGF recipients recovered to normal 20 45 days after operation.There was no significant difference between the two groups in the mean creatinine creatinine (creatinine) on the 7th day after operation, in the LifePort group (93.61 卤25.05 umol/ L) and the traditional ice bucket group (106.79 卤34.27 umol/ L). There was no significant difference between the two groups in the mean time of serum creatinine recovery to normal in the P0.05-LifePort group (5.39 卤0.97 days).The mean time of serum creatinine recovery in the traditional ice bucket group was 15.38 卤3.9 days, and the difference between the two groups was significant (P 0.05).There were 2 cases of acute rejection in perioperative period, the incidence of acute rejection was 7.6 / 26) among them, one case in LifePort group was 1 / 13 in LifePort group, and one case in traditional ice bucket group. There was no significant difference in the incidence of acute rejection between the two groups (P 0.05), all of which were reversed after treatment.Conclusion: preservation of DCD donor kidney with LifePort can shorten the time of renal function recovery, and can significantly reduce the incidence of DGF after renal transplantation.Using LifePort to preserve DCD donor kidney is safe and reliable.
【学位授予单位】：吉林大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R699.2

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