血清α-klotho水平与肥胖相关性肾小球病发病之间的相关关系分析

发布时间：2018-04-21 20:07

本文选题：肥胖 + 肥胖相关性肾小球病　；参考：《首都医科大学》2017年硕士论文

【摘要】：目的血清分泌型α-klotho蛋白参与能量代谢调节,但其水平与肥胖相关肾小球病(obesity-related glomerulonepathy,ORG)间关系未见报道。本研究检测不同肥胖人群的血清α-klotho蛋白水平,探讨其与肥胖相关性肾小球病(ORG)发病之间的相关关系。方法选取经肾穿刺病理检查确诊为ORG的患者48例,以及性别、年龄、体质指数与之匹配的单纯性肥胖患者及肥胖慢性肾脏病(CKD)患者各48例,分别收集他们的临床资料和检验指标,并采用酶联免疫吸附测定法(ELISA)检测血清α-klotho蛋白浓度。结果单因素组间比较显示,ORG组的血清α-klotho蛋白水平中位数为572.66(439.92,690.58)pg/ml,显著低于单纯性肥胖组中位数值635.85(559.52,769.20)pg/ml和肥胖CKD组中位数值690.30(516.15,828.20)pg/ml(P0.01)。多分类多因素Logistic回归分析显示,血清α-klotho蛋白与ORG的发病独立相关,ORG组分别与单纯性肥胖组和肥胖CKD组相比,血清α-klotho蛋白每增加100pg/ml,ORG的发病风险各降低35%(OR值:0.652,95%可信区间:0.487~0.872)和38%(OR值:0.617,95%可信区间:0.453~0.832)。结论血清α-klotho蛋白水平在ORG患者中显著降低,与ORG的发病独立相关,α-klotho可能是拮抗ORG发病的保护因子。
[Abstract]:Objective Serum secretory 伪 -klotho protein is involved in the regulation of energy metabolism, but the relationship between the level of 伪 -klotho protein and obesity-related glomerulonephritis (ORG) has not been reported. In this study, the serum 伪 -klotho protein levels were measured in different obese subjects, and the correlation between 伪 -klotho protein and the incidence of obesity associated glomerulonephritis (ORG) was investigated. Methods 48 patients with ORG diagnosed by renal biopsy, 48 patients with simple obesity matched by sex, age and BMI, and 48 patients with obese chronic kidney disease were selected. Their clinical data and test indexes were collected, and the serum 伪 -klotho protein concentration was detected by enzyme linked immunosorbent assay (Elisa). Results the median level of serum 伪 -klotho protein in ORG group was 572.66 ~ 439.92690.58 g / ml, which was significantly lower than that in simple obesity group (635.85(559.52769.20)pg/ml) and obese CKD group (690.30) 516.15828.20 渭 g / ml / ml P0.01. Results the median level of 伪 -klotho protein in ORG group was 572.66 ~ 439.92690.58 g / ml, which was significantly lower than that in simple obesity group and obese CKD group. Multivariate Logistic regression analysis showed that serum 伪 -klotho protein was correlated with the incidence of ORG in ORG group, compared with simple obesity group and obese CKD group, respectively. The risk of 伪 -klotho protein increased by 100pg / ml ORG decreased the 35%(OR value of 0: 0. 652% 95% confidence interval: 0. 487% 0. 872%) and the 38%(OR value of 0. 617% 95% confidence interval: 0. 453% 0. 832%. Conclusion the level of serum 伪 -klotho protein is significantly lower in patients with ORG, which is independent of the pathogenesis of ORG. 伪 -klotho may be a protective factor against the pathogenesis of ORG.
【学位授予单位】：首都医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R692.6

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