中西医结合男科病证结合疗效机制研究的困惑与对策

发布时间：2018-04-27 22:38

本文选题：男科 + 中西医结合　；参考：《中华男科学杂志》2017年07期

【摘要】：中西医结合男科疗效机制的研究越来越成为行业的热点。然而,目前许多中西医结合男科疗效机制的研究难以诠释中西医结合男科的内涵,主要体现在不同中医治则、中药复方专方正在进行着作用于同一机制效应指标的重复研究,重病轻证的研究普遍存在,不成熟的证候模型仍成为机制研究的手段,不确定的、不成熟的靶点机制仍成为研究的热点,如此耗费人力物力仍无法诠释男科中医辨证论治的精华及中西医结合辨病辨证取效的机制所在。中西医结合男科疗效机制研究的着眼点要求我们不仅要说明中药复方专方对男科疾病的疗效机制,更重要的是能阐明中医辨证论治的本质。近些年来蛋白质组学、基因组学、转录组学和代谢组学为中西医结合男科病证结合疗效机制研究提供了重要线索,通过对"证"的把握,从宏观整体归纳分析,发展到微观基因、蛋白、代谢、元基因组等角度分析,从而寻求中西医男科病证结合研究的突破口,创新中国特色男科。
[Abstract]:The research of therapeutic effect mechanism of integrated traditional Chinese and western medicine has become a hot spot in the field. However, at present, many studies on the therapeutic effect mechanism of integrated traditional Chinese and western medicine are difficult to interpret the connotation of integrated traditional Chinese and western medicine andrology, mainly reflected in different principles of traditional Chinese medicine treatment. The research of serious disease and light syndrome is widespread, immature syndrome model still becomes the means of mechanism research, uncertain and immature target mechanism still becomes the hot spot of research. So expend manpower and material resources still can not explain the essence of TCM dialectical treatment of andrology and the mechanism of integrated TCM and western medicine syndrome differentiation. The focus of the research on the mechanism of therapeutic effect of integrated traditional Chinese and western medicine in andrology requires us not only to explain the mechanism of curative effect of traditional Chinese medicine compound prescription on andrology diseases, but also to clarify the essence of syndrome differentiation and treatment of traditional Chinese medicine. In recent years, proteomics, genomics, transcriptome and metabolomics have provided important clues for the study of the therapeutic effect of the combination of diseases and syndromes between traditional Chinese and western medicine. The microanalysis of gene, protein, metabolism, meta genome and so on was carried out to find a breakthrough in the research of the combination of diseases and syndromes of traditional Chinese and western medicine, and to innovate the andrology with Chinese characteristics.
【作者单位】：福建中医药大学附属人民医院男科;
【基金】：国家自然科学基金(81573743);国家自然科学基金青年科学基金(81403246)~~
【分类号】：R697

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