肠道功能紊乱与慢性肾脏病

发布时间：2018-04-28 00:07

本文选题：肠道菌群 + 肠黏膜上皮屏障　；参考：《肾脏病与透析肾移植杂志》2017年05期

【摘要】：越来越多的研究表明,慢性肾脏病(CKD)患者普遍存在炎症反应,且炎症反应可加快CKD的进展。多种因素参与了CKD介导的全身炎症反应及氧化应激反应。近期有研究发现肠道菌群的改变及肠黏膜上皮屏障功能失调与CKD有密切联系。CKD患者肠道菌群的种类及数量常发生改变,肠黏膜上皮细胞的紧密连接受损,肠道渗透压升高,毒素进入血液,引起全身炎症反应及氧化应激反应,从而导致CKD进展。本文就肠道菌群及肠黏膜上皮屏障功能与CKD关系作一综述。
[Abstract]:More and more studies have shown that chronic kidney disease (CKD) patients have a common inflammatory response, and inflammatory response can accelerate the progress of CKD. Many factors are involved in CKD mediated systemic inflammation and oxidative stress. Recent studies have found that the alteration of intestinal flora and the dysfunction of intestinal mucosal epithelial barrier are closely related to CKD. The types and quantity of intestinal flora often change, the tight connection of intestinal mucosal epithelial cells is damaged, and the intestinal osmotic pressure is increased. Toxins enter the blood, causing systemic inflammation and oxidative stress, leading to the progression of CKD. This article reviews the relationship between intestinal flora and intestinal mucosal epithelial barrier function and CKD.
【作者单位】：南京大学医学院附属金陵医院(南京总医院);南京大学医学院附属金陵医院(南京总医院)国家肾脏疾病临床医学研究中心全军肾脏病研究所;
【基金】：国家自然科学基金(81470944)
【分类号】：R692

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