福州地区成年人血清γ谷氨酰转肽酶与慢性肾脏病危险因素关系的研究

发布时间：2018-05-04 22:39

本文选题：血清γ谷氨酰转肽酶 + 慢性肾脏病　；参考：《福建医科大学》2014年硕士论文

【摘要】：目的：观察福州地区成年人体检资料，研究血清γ谷氨酰转肽酶（GGT）与慢性肾脏病（CKD）发病危险因素之间的相关性。探讨各危险因素对GGT的影响程度，以利于早期慢性肾脏病的预防。方法：回顾性分析2014年1月在福建省立医院的体检者资料，经过纳入标准和排除标准的筛选，分析了其中资料完整的354人，，利用相应的统计学方法对血清GGT进行分组，分别计算与甘油三酯（TG）、胆固醇（TC）、低密度脂蛋白（LDL）、血糖（GLU）、血尿酸（UA）、收缩压（SBP）、舒张压（DBP）等CKD危险因素的相关系数、线性关系和OR值。结果：1、校正年龄、性别等，血清GGT与其他项目做Spearman相关分析显示：血清GGT含量与其余指标的相关系数如下（男/女）：TG（0.431/0.406）、TC（0.253/0.249）、LDL（0.262/0.296）、UA（0.287/0.370）、SBP(0.12/0.322）、DBP(0.283/0.205），其中女性血清GGT含量还与年龄呈正相关（0.307）。以上P0.05。 2、将血清GGT按照四分位数分级，各变量以（x±s）表示。组间差异使用非参数秩和检验（Kruskal-Wallis）。结果显示随着GGT分组数值增大，男性的TG、TC、LDL、GLU、UA、DBP数值逐渐增大，女性的年龄、TG、TC、LDL、GLU、UA、SBP、DBP数值逐渐增大。以上P0.05，组间差异有统计学意义。 3、校正性别、年龄等，使用多元逐步线性回归建模，结果提示GGT的变化与TG、UA、FBG呈正线性关系，β值分别为0.375、0.243、0.194，以上P0.05，有统计学意义。其中TG、UA对GGT的影响最大。 4、校正性别、年龄等，将血清GGT和CKD的危险因素进行多元Logistic回归并计算OR值。结果显示随GGT分组增大，上述危险因素的OR值(95%可信区间)逐渐升高，提示GGT的升高增加了CKD危险因素的暴露程度。结论：福州地区成年人男性血清GGT与年龄（女性）、TG、TC、LDL、GLU、UA、血压等呈正相关关系。即使在正常范围内，这种关系也存在。随着GGT分组增大，出现多个CKD危险因素的比例在增加。正常范围内的GGT与TG、FBG、UA呈线性关系。血清GGT与高脂血症、高尿酸血症、高血糖、高血压等CKD危险因素的发病相关，提示血清GGT可能是CKD的一个相关危险因子。
[Abstract]:Objective: to investigate the correlation between serum 纬 -glutamyl transpeptidase (GGTT) and chronic kidney disease (CKD) risk factors. To investigate the influence of various risk factors on GGT in order to prevent early chronic kidney disease. Methods: the data of examiners in Fujian Provincial Hospital in January 2014 were analyzed retrospectively. After screening by inclusion criteria and exclusion criteria, 354 patients with complete data were analyzed, and serum GGT was grouped by the corresponding statistical method. The correlation coefficients, linear relationships and OR values of CKD risk factors, such as triglyceride TGG, TC, LDL, GLU, SBP, SBP and DBP, were calculated respectively. Results: 1, adjusted age, sex, serum GGT and other items, Spearman correlation analysis showed that the correlation coefficient between serum GGT content and other indexes was as follows (male / female: TGG 0.43 1 / 0.406% TC0.253 / 0.249% LDLX 0.262% 0.296UA0.2870% 0.370% SBP 0.12 / 0.322% 0.283 / 0.205), and the female serum GGT content was positively correlated with the age of 0.307%. Above P0.05. 2. The serum GGT was classified according to quartile, and the variables were expressed as x 卤s. Nonparametric rank sum test was used to test the differences between groups. The results showed that with the increase of GGT grouping value, the values of GGT increased gradually in males and increased in females. The above P 0.05, the difference between groups was statistically significant. 3. Sex and age were corrected, and multiple stepwise linear regression models were used. The results showed that the change of GGT was positively linear with 尾 values of 0.375 卤0.243 and 0.194, respectively (P > 0.05). TGG UA had the greatest influence on GGT. The risk factors of serum GGT and CKD were analyzed by multivariate Logistic regression and OR values were calculated. The results showed that the OR value (95% CI) of the above risk factors increased with the increase of GGT group, suggesting that the increase of GGT increased the exposure of CKD risk factors. Conclusion: there is a positive correlation between serum GGT and age (TGG), LDL, GLU UAA, blood pressure and so on. Even in the normal range, this relationship exists. As the GGT grouping increases, the proportion of multiple CKD risk factors increases. There was a linear relationship between GGT and TGG FBGG UA in normal range. Serum GGT was associated with hyperlipidemia, hyperuricemia, hyperglycemia, hypertension and other risk factors of CKD, suggesting that serum GGT may be a related risk factor of CKD.
【学位授予单位】：福建医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R692

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