原发性肾病综合征患者尿视黄醇结合蛋白水平的变化及临床意义

发布时间：2018-05-05 18:50

本文选题：尿视黄醇结合蛋白 + 原发性肾病综合征　；参考：《皖南医学院》2014年硕士论文

【摘要】：目的：探讨原发性肾病综合征（NS）患者尿视黄醇结合蛋白水平的变化及其临床意义和肾小管间质损伤机制方法：检测30例确诊并行肾脏穿刺病理学组织活检的原发性NS患者以及30例正常人作对照组，以上60例分别测定尿常规项目以及肾小管功能损害指标—尿视黄醇结合蛋白（RBP），，尿α1微球蛋白（α1-MG）、尿β2-微球蛋白（β2-MG）、N-乙酰-β-D-尿氨基葡萄糖苷酶（NAG）含量，按生化检测指标和肾小管间质的损害程度评分进行Spearman等级相关分析。分析各组间RBP以及RBP与其他指标间的差异及相关性。结果：肾小管间质损伤与尿RBP,α1-MG,β2-MG,NAG呈正相关（分别r=0.950，P＜0.01；r=0.837,P＜0.01；r=0.800，P＜0.01；r=0.957,P＜0.01）；尿RBP对肾小管间质损害的特异性和敏感性分别为88.89%和90.48%。结论：尿RBP可以在早期敏感的反映原发性NS患者肾小管间质的病理损害程度，较NAG、α1-MG、β2-MG更敏感，并且与肾小管间质损害程度呈正相关。
[Abstract]:Objective: To investigate the changes of urinary retinol binding protein level in patients with primary nephrotic syndrome (NS) and its clinical significance and the mechanism of tubulointerstitial injury.
Methods: 30 cases of primary NS and 30 normal subjects were tested for pathological biopsy of renal biopsy. The above 60 cases were tested for urine routine items and renal tubule function impairment, urinary retinol binding protein (RBP), urinary alpha 1 microglobulin (alpha 1-MG), urinary beta 2- microglobulin (beta 2-MG), N- acetyl - beta -D- urine ammonia The content of glucosidase (NAG) was analyzed by Spearman level correlation according to biochemical test index and renal tubulointerstitial damage score. The difference and correlation between RBP and RBP and other indexes were analyzed.
Results: the renal tubulointerstitial damage was positively correlated with urinary RBP, alpha 1-MG, beta 2-MG, NAG (r=0.950, P < 0.01, r=0.837, P < 0.01, r=0.800, P < 0.01, r=0.957, P < 0.01); the specificity and sensitivity of urinary tract to renal tubulointerstitial damage were 88.89% and 88.89% respectively.
Conclusion: urinary RBP can reflect the pathological damage of renal tubulointerstitium in early NS patients, which is more sensitive than NAG, alpha 1-MG, beta 2-MG, and is positively related to the degree of renal tubulointerstitial damage.

【学位授予单位】：皖南医学院
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R692

【共引文献】