老年晚期慢性肾脏病患者颈动脉粥样硬化与甲状腺激素的相关性

发布时间：2018-05-07 04:33

本文选题：肾脏病 + 颈动脉粥样硬化　；参考：《中国老年学杂志》2017年18期

【摘要】：目的测量老年晚期慢性肾脏病患者的甲状腺激素水平,探讨其与颈动脉粥样硬化的相关性。方法选择老年晚期慢性肾脏病患者140例,根据是否存在颈动脉粥样硬化分为慢性肾脏病合并颈动脉粥样硬化组(观察组)69例和慢性肾脏病不合并颈动脉粥样硬化组(对照组)71例。测定促甲状腺激素(TSH)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、C反应蛋白(CRP)、颈动脉内膜中层厚度(CIMT)。结果观察组年龄及吸烟比例明显大于对照组(P0.05);两组性别和平均动脉压比较无统计学差异(P0.05);观察组FT3水平明显低于对照组(P0.05),两组TSH和FT4水平无统计学差异(P0.05);观察组CIMT、TG、TC、LDL-C、CRP均明显高于对照组(P0.05),观察组HDL-C显著低于对照组(P0.05)。观察组血清FT3水平与CIMT、TG、TC、LDL-C、CRP水平呈负相关(P0.05),与HDL-C水平呈正相关(P0.05)。结论血清FT3水平下降和老年晚期慢性肾脏病合并颈动脉粥样硬化的发生有关,可能通过血脂异常和炎症反应参与动脉粥样硬化的发生。
[Abstract]:Objective to investigate the relationship between thyroid hormone and carotid atherosclerosis in elderly patients with advanced chronic kidney disease. Methods 140 elderly patients with advanced chronic kidney disease were selected. According to the existence of carotid atherosclerosis, there were 69 cases of chronic kidney disease complicated with carotid atherosclerosis (observation group) and 71 cases of chronic kidney disease without carotid atherosclerosis group (control group 71 cases). Thyroid stimulating hormone (TSH), free triiodothyronine (FT3), free thyroxine (FT4), triglyceride (TGN), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) -reactive protein (HDL-C) and carotid intima-media thickness (CIMT) were determined. Results the age and smoking ratio in the observation group were significantly higher than those in the control group (P 0.05), there was no significant difference in gender and mean arterial pressure between the two groups (P 0.05), the level of FT3 in the observation group was significantly lower than that in the control group (P 0.05), and there was no significant difference in the levels of TSH and FT4 between the two groups (P 0.05). The levels of HDL-C in the observation group were significantly higher than those in the control group (P 0.05), and the levels of HDL-C in the observation group were significantly lower than those in the control group (P 0.05). In the observation group, the serum FT3 level was negatively correlated with the level of CIMT TGN LDL-Cn, and was positively correlated with the HDL-C level (P 0.05). Conclusion the decrease of serum FT3 level is related to the occurrence of carotid atherosclerosis in elderly patients with advanced kidney disease, and may be involved in the occurrence of atherosclerosis through abnormal blood lipid and inflammatory reaction.
【作者单位】：金华市人民医院肾内科;金华市人民医院西药房;
【分类号】：R692

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