磷霉素对尿路感染患者肠杆菌科细菌的敏感性分析

发布时间：2018-05-08 11:32

本文选题：磷霉素 + 尿路感染　；参考：《中华医院感染学杂志》2017年12期

【摘要】：目的了解磷霉素对尿路感染患者肠杆菌科细菌的敏感性,指导临床合理用药。方法对2016年1-9月医院尿路感染患者清洁中段尿标本进行培养,共分离出肠杆菌科病原菌678株,使用BD-phoenix-100对尿路感染患者中段尿分离肠杆菌科细菌进行鉴定和药敏试验及产超广谱β-内酰胺酶(ESBLs)的检测,磷霉素药敏试验采用纸片扩散法测定,结果按CLSI 2015年版标准判断;应用WHONET 5.6软件分析分离株的分布和耐药情况。结果共分离678株肠杆菌科细菌,以大肠埃希菌为主,共510株占75.2%;肠杆菌科细菌对磷霉素的敏感率为92.3%;大肠埃希菌、肺炎克雷伯菌、奇异变形杆菌中产ESBLs检出率分别为41.4%、38.2%、6.1%;产ESBLs大肠埃希菌、肺炎克雷伯菌对磷霉素的敏感率分别为94.3%、9.5%。结论尿路感染病原菌以大肠埃希菌、肺炎克雷伯菌为主,磷霉素对尿路感染病原菌(包括产ESBLs细菌)具有较好的敏感性,可作为临床首选的经验用药。
[Abstract]:Objective to investigate the sensitivity of fosfomycin to Enterobacteriaceae in patients with urinary tract infection and to guide rational drug use. Methods A total of 678 strains of Enterobacteriaceae pathogenic bacteria were isolated from clean urine samples of patients with urinary tract infection from January to September 2016. BD-phoenix-100 was used to identify enterobacteriaceae isolated from middle urinary tract infection patients and to detect drug sensitivity test and extended-spectrum 尾 -lactamase (ESBLs) production. The drug sensitivity test of fosfomycin was determined by disc diffusion method. The results were judged according to the standard of CLSI 2015. The distribution and drug resistance of the isolates were analyzed by WHONET 5.6 software. Results A total of 678 strains of Enterobacteriaceae were isolated, of which 510 strains were Escherichia coli (75.2%), the sensitivity rate of Enterobacteriaceae to fosfomycin was 92.3%, Escherichia coli, Klebsiella pneumoniae, The detectable rate of ESBLs in Proteus mirabilis was 41.4 and 38.2%, respectively, and the sensitivity rates of Escherichia coli and Klebsiella pneumoniae to fosfomycin were 94.33.3 and 9.50.The sensitivity rates of Escherichia coli and Klebsiella pneumoniae to fosfomycin were 94. 3% and 9. 5% respectively. Conclusion Escherichia coli and Klebsiella pneumoniae are the main pathogens of urinary tract infection. Fosfomycin is sensitive to the pathogens of urinary tract infection (including ESBLs producing bacteria) and can be used as the first choice in clinical practice.
【作者单位】：长江大学附属第一医院检验科;
【基金】：湖北省卫生计生科研基金(WJ2016-Y-33)
【分类号】：R446.5;R691.3

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