小剂量环孢素A单药治疗特发性膜性肾病临床分析

发布时间：2018-05-08 12:47

本文选题：特发性膜性肾病 + 环孢素A　；参考：《中国实用内科杂志》2016年10期

【摘要】：目的回顾性分析小剂量环孢素A(Cs A)单药治疗特发性膜性肾病的疗效。方法回顾性分析2008年9月至2015年12月北京大学第一医院收治的Cs A[1~3 mg/(kg·d)]单药治疗的特发性膜性肾病患者,收集临床随访资料。统计完全缓解率、部分缓解率、无效率,缓解后的复发情况。结果 36例患者符合入选标准。Cs A单药治疗时间为(15.56±8.86)个月,随访均大于12个月。治疗6个月缓解率67.7%(24/36),其中完全缓解11.1%(4/36),部分缓解55.6%(20/36);治疗12个月缓解率58.3%(21/36),其中完全缓解25.0%(9/36),部分缓解33.3%(12/36);5例(20.8%)部分缓解患者复发;在长期随访中,42.9%的缓解患者复发。结论小剂量环孢素A单药治疗特发性膜性肾病有效,可避免联合糖皮质激素治疗的副反应;但应注意缓解后有一定比例的复发。
[Abstract]:Objective To retrospectively analyze the efficacy of small dose cyclosporin A (Cs A) single drug in the treatment of idiopathic membranous nephropathy. Methods the patients with idiopathic membranous nephropathy treated with single drug Cs A[1~3 mg/ (kg / D) in No.1 Hospital of Peking University from September 2008 to December 2015 were retrospectively analyzed, and the clinical follow-up data were collected. The rate of complete remission, partial remission rate, and no rate of remission were statistically analyzed. Results in 36 patients, 36 patients met the standard of admission (15.56 + 8.86 months) and were followed up for more than 12 months. The remission rate was 67.7% (24/36) for 6 months, including complete remission 11.1% (4/36), partial remission 55.6% (20/36), and 58.3% (21/36) for 12 months, of which 25% (9/36) was completely relieved. Remission of 33.3% (12/36); 5 cases (20.8%) remission of patients; 42.9% of remission in long-term follow-up. Conclusion small dose cyclosporin single drug is effective in the treatment of idiopathic membranous nephropathy and can avoid side effects combined with glucocorticoid therapy; however, a certain proportion of recurrence should be paid attention to after remission.

【作者单位】：北京大学第一医院肾内科北京大学肾脏病研究所;福建中医药大学附属第二人民医院肾内科;
【基金】：国家自然科学基金创新研究群体项目(81321064) 首都临床特色应用研究(Z161100000516039)
【分类号】：R692

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