内分泌治疗和中药协同治疗对前列腺癌患者前列腺特异性抗原动态变化与疾病预后的相关分析

发布时间：2018-05-10 13:40

本文选题：前列腺癌 + 内分泌治疗　；参考：《中华中医药学刊》2017年05期

【摘要】：目的:观察前列腺癌患者采用内分泌治疗后前列腺特异性抗原(PSA)的变化水平,并且评价相关的临床预后指标同时。方法:前瞻性收集2010年6月—2015年6月华北理工大学附属医院入院收治的前列腺组织病理确诊前列腺癌患者58例,随机分为内分泌治疗组与对照组,内分泌治疗组患者在对照组常规治疗基础上结合比卡鲁胺、中药予以治疗,对照组为常规方案。比较观察两组患者前列腺特异性抗原(PSA)的变化水平和卡氏(KPS)评分,并通过SAS自评量表评价两组治疗效果。结果:两组治疗方法均可有效改善前列腺癌患者PSA水平。内分泌治疗组79.3%患者PSA水平恢复正常,高于对照组69.0%,但两组间无明显统计学差异(χ2=2.599,P=0.107)。内分泌治疗组KPI评分70分患者为72.4%,高于对照组62.1%,但两组间无明显统计学差异(χ2=2.261,P=0.133)。内分泌治疗组SAS自评量表评分改善患者多于对照组,但两组间无明显统计学差异(P0.05)。结论:前列腺癌内分泌治疗能有效降低患者PSA水平、改善患者生活质量,与常规治疗具有等同疗效。
[Abstract]:Aim: to observe the changes of prostate specific antigen (PSAs) in patients with prostate cancer after endocrine therapy and to evaluate the clinical prognostic indexes. Methods: from June 2010 to June 2015, 58 prostate cancer patients admitted to the affiliated Hospital of Huabei University of Science and Technology were randomly divided into endocrine therapy group and control group. The patients of endocrine therapy group were treated with traditional Chinese medicine on the basis of routine therapy in control group, while those in control group were treated with traditional Chinese medicine. The changes of prostate specific antigen (PSA) and KPS score were compared between the two groups, and the therapeutic effects were evaluated by SAS self-rating scale. Results: both groups were effective in improving the PSA level of prostate cancer patients. The PSA level in the endocrine treatment group (79.3%) returned to normal, which was higher than that in the control group (69.0%), but there was no significant difference between the two groups (蠂 ~ 2 / 2.599). The KPI score in the endocrine treatment group was 72.4, which was higher than that in the control group (62.1), but there was no significant difference between the two groups (蠂 ~ 2 / 2.261P = 0.133). The scores of SAS in endocrine therapy group were more than those in control group, but there was no significant difference between the two groups (P 0.05). Conclusion: endocrine therapy for prostate cancer can effectively reduce the level of PSA and improve the quality of life of patients.
【作者单位】：华北理工大学附属医院泌尿外科;
【分类号】：R737.25

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