PEDF和VTN在前列腺癌及前列腺增生中的表达及意义

发布时间：2018-05-10 19:22

本文选题：前列腺癌 + 前列腺增生　；参考：《新疆医科大学》2014年硕士论文

【摘要】：目的：研究PEDF和VTN在人前列腺癌组织、良性前列腺增生组织中的表达情况,探讨其表达与前列腺癌的相关性及临床意义。方法：利用免疫组织化学观察PEDF和VTN在前列腺癌组织和良性前列腺增生组织中的表达情况,并对其结果进行统计学分析。结果：免疫组化显示PEDF和VTN在前列腺癌组织中的表达在前列腺癌组和前列腺增生组中的表达有统计学的显著性意义(P=0.011,P=0.008)。前列腺癌组织中PEDF和VTN表达在不同年龄无明显差异(P=0.345,P=0.434)；前列腺癌组织中PEDF的表达强度与患者术前血清PSA、Gleason评分、临床分期及肿瘤有无转移之间存在明显差异(P0.05)；前列腺癌组织中VTN的表达强度与患者Gleason评分、临床分期及肿瘤有无转移之间的差异有统计学意义(P0.05),而与术前血清PSA的差异无统计学意义。结论：1、PEDF和VTN在前列腺癌组中和前列腺增生组的表达差异具有统计学意义,提示通过对其检测可能会对前列腺癌的诊断有一定的帮助。2、在前列腺癌中,PEDF的表达与血清PSA、Gleason评分、临床分期及肿瘤有无转移均有统计学意义,提示其在前列腺癌发生、发展过程中发挥重要作用。3、在前列腺癌中,VTN的表达强度与Gleason评分、临床分期及肿瘤有无转移之间的差异具有统计学意义,而与术前血清PSA的差异无相关性。4、PEDF和VTN对于前列腺癌患者的疾病诊断、病情评估、疗效评价以及预后等方面也可能有指导性的意义。
[Abstract]:Objective: to study the expression of PEDF and VTN in human prostate cancer and benign prostatic hyperplasia (BPH), and to explore the relationship between the expression and the clinical significance. Methods: immunohistochemistry was used to observe the expression of PEDF and VTN in prostate cancer and benign prostatic hyperplasia (BPH), and the results were analyzed statistically. Results: immunohistochemical staining showed that the expression of PEDF and VTN in prostate cancer and prostatic hyperplasia was significantly higher than that in control group. There was no significant difference in the expression of PEDF and VTN in prostate cancer tissues at different ages. The expression of PEDF in prostate cancer tissues was correlated with the preoperative serum PSA-Gleason score. There was significant difference between clinical stage and tumor metastasis (P 0.05). The expression of VTN in prostate cancer tissues and the Gleason score of the patients were significantly different. The difference of clinical stage and tumor metastasis was statistically significant (P 0.05), but there was no significant difference between the clinical stage and preoperative serum PSA. Conclusion the differences between the expression of PEDF and VTN in prostate cancer and prostatic hyperplasia are statistically significant. It is suggested that the detection of PEDF may be helpful in the diagnosis of prostate cancer, and the expression of PEDF in prostate cancer and the serum PSA-Gleason score may be helpful to the diagnosis of prostate cancer. The clinical stage and tumor metastasis were statistically significant, suggesting that they play an important role in the occurrence and development of prostate cancer. The expression intensity of VTN and Gleason score in prostate cancer. The difference of clinical stage and tumor metastasis was statistically significant, but there was no correlation between the difference of serum PSA and preoperative VTN in the diagnosis and evaluation of the disease in patients with prostate cancer. The evaluation of curative effect and prognosis may also have instructive significance.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R737.25

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