腹透患者残肾功能与血管内皮功能的相关性

发布时间：2018-05-11 12:21

本文选题：血管内皮细胞功能紊乱 + 残肾功能　；参考：《广东医学》2017年20期

【摘要】：目的探讨维持性腹膜透析患者残肾功能与血管内皮功能的相关性。方法选取本院腹透中心维持性腹透患者101例进行横断面研究,平均年龄(47.4±12.3)岁,男55例,平均透析龄(23.4±19.7)个月。收集相关临床资料及实验室检查数据,计算残肾肾小球滤过率(GFR)以评估残肾功能,使用B超检测肱动脉血管舒张功能(FMD)以评估血管内皮功能。根据FMD和残肾GFR进行分组,比较不同分组患者相关指标的差别,用Pearson相关性分析法分析FMD与残肾功能的相关性,用多因素logistic分析法分析腹透患者发生内皮功能紊乱的危险因素。结果正常FMD组患者残肾GFR显著高于低FMD组患者,而高残肾GFR组患者FMD显著高于低残肾GFR组患者。相关性分析显示残肾GFR、残肾Kt/V及总Kt/V与FMD呈正相关,年龄、透析龄、脉压、超敏C反应蛋白(hs-CRP)及4 h D/Pcr与FMD呈负相关。多因素logistic分析显示残肾GFR、年龄及log hs-CRP是FMD的独立危险因素。结论腹透患者血管内皮功能与残肾功能相关,残肾功能的动态评估有助于预测血管内皮功能的变化。
[Abstract]:Objective to investigate the relationship between residual renal function and vascular endothelial function in maintenance peritoneal dialysis patients. Methods A cross-sectional study was conducted in 101 patients with central maintenance dialysis in our hospital. The mean age was 47.4 卤12.3 years old, 55 males, with an average dialysis age of 23.4 卤19.7months. Relevant clinical data and laboratory data were collected to evaluate residual renal function by calculating glomerular filtration rate (GFR) and vascular diastolic function (FMDD) of brachial artery were measured by B-ultrasound to evaluate vascular endothelial function. According to FMD and residual kidney GFR, we compared the difference of relative indexes between different groups. The correlation between FMD and residual renal function was analyzed by Pearson correlation analysis, and the risk factors of endothelial dysfunction in patients with abdominal dialysis were analyzed by multivariate logistic analysis. Results GFR of residual kidney in normal FMD group was significantly higher than that in low FMD group, while FMD in high residual GFR group was significantly higher than that in low residual renal GFR group. Correlation analysis showed that GFR, Kt/V and total Kt/V were positively correlated with FMD. Age, dialysis age, pulse pressure, hypersensitive C-reactive protein hs-CRP) and 4 h D/Pcr were negatively correlated with FMD. Multivariate logistic analysis showed that GFR, age and log hs-CRP were independent risk factors for FMD. Conclusion Endothelial function is related to residual renal function in peritoneal dialysis patients. Dynamic evaluation of residual renal function is helpful to predict the changes of vascular endothelial function.
【作者单位】：泰兴市人民医院肾内科、泰州市肾脏病临床研究中心;
【基金】：江苏省卫生计生委2015年度指导性科研课题(编号:Z201525)
【分类号】：R692.5

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