广西防城港地区男性血清免疫球蛋白与前列腺炎样症状、EPS中白细胞数量的相关性的调查研究

发布时间：2018-05-12 23:33

本文选题：血清免疫球蛋白 + NIH-CPSI　；参考：《广西医科大学》2014年硕士论文

【摘要】：目的：本研究旨在探究广西防城港地区男性人群中血清免疫球蛋白与前列腺炎样症状、EPS中白细胞数量的相关性。研究设计和方法：2009年，我们对广西防城港地区男性健康队列（Fangchenggang Area Male Health and Examination Survey，FAMHES）进行了第一次随访，并对4303名年龄在17-88岁男性进行问卷调查。调查表包括美国国立卫生研究院慢性前列腺炎症状指数（NIH-CPSI），社会人口学资料，生活方式特点，经统一培训的人测量身高、体重和血压。抽静脉血测定空腹血糖、胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇和血清IgA、IgG、IgM。并接受前列腺按摩取得EPS，标本行常规涂片法WBC计数。采用SPSS16.0软件来处理与分析数据。结果：我们研究纳入的523例健康体检男性中，其中前列腺炎样症状组为62人，非前列腺炎样症状组为416人，血清IgA、IgG、IgM在两组间差异无统计学意义（P0.05）。在总纳入人群、前列腺炎样症状组、非前列腺炎样症状组中，血清IgA、IgG、IgM与EPS中的WBC数量都无线性相关性（P0.05）。在总纳入人群的二元logistics回归分析中，校正了年龄、运动和教育水平等混杂因素后，血清IgA、IgG、IgM与前列腺炎样症状的发生仍无显著关联（P0.05）。在前列腺炎样症状者中，血清IgA在2.15-2.69g/L的体检者中度或重度前列腺炎样排尿症状发生风险最高（OR=2.65；95%CI=1.08~5.14）。调整年龄、运动、受教育水平作为混杂变量后，，血清IgA对中度或重度前列腺样排尿症状仍存在效应，OR值有所上升。血清IgA水平增高，中度或重度前列腺炎样排尿症状发生风险升高（OR=2.73，95%CI=1.34-5.78；OR=2.67，95%CI=1.12-5.56）。结论：我们的研究显示在中国的男性人群中，血清IgA、IgG、IgM与前列腺炎样症状的发生无关，血清IgA、IgG、IgM与前列腺炎症程度无相关关系，不适合作为前列腺炎的诊断指标。升高的血清IgA与中度或重度前列腺炎样排尿症状相关，免疫反应可能参与前列腺炎样症状的疾病进程。因此，未来我们应该更关注患者前列腺炎样症状，予以针对性的免疫治疗。
[Abstract]:Objective: to investigate the correlation between serum immunoglobulin (Ig) and leukocyte count in prostatitis like symptoms (EPS) in male population in Fangchenggang area, Guangxi. Research design and methods: in 2009, we conducted the first follow-up study of Fangchenggang Area Male Health and Examination Survey Fam HES in Fangchenggang Health Cohort in Fangchenggang, Guangxi. A questionnaire survey was conducted among 4303 males aged 17-88 years. The questionnaire included the National Institutes of Health (NIH) chronic Prostatitis symptom Index (NIH-CPSIN), socio-demographic data, lifestyle characteristics, and uniform training to measure height, weight and blood pressure. Fasting blood glucose, cholesterol, triglyceride, high density lipoprotein cholesterol, low density lipoprotein cholesterol and serum IgA G G C were measured. EPSs were obtained by prostate massage, and the specimens were counted by routine smear WBC. SPSS16.0 software is used to process and analyze the data. Results: among the 523 healthy men, 62 were in the prostatitis like symptom group and 416 in the non-prostatitis like symptom group. There was no linear correlation between serum IgA EPS and WBC levels in the total population, prostatitis like symptom group and non-prostatitis like symptom group. After adjusting for the mixed factors of age, exercise and education, there was no significant correlation between serum IgA logistics and prostatitis like symptoms. Among the patients with prostatitis like symptoms, the patients with moderate or severe prostatitis urination symptoms with serum IgA in 2.15-2.69g/L had the highest risk of occurrence. After adjusting for age, exercise and education, the OR value of serum IgA on moderate or severe prostatic urination was increased. The level of serum IgA was increased, and the risk of moderate or severe prostatitis like urination was increased. Conclusion: our study shows that in Chinese male population, there is no correlation between serum IgA + IgG + IgM and prostatitis like symptoms, but no correlation between serum IgA + IgG + IgM and prostatic inflammation, so it is not suitable to be used as a diagnostic index for prostatitis. Elevated serum IgA is associated with moderate or severe prostatitis like urination, and immune response may be involved in the progression of prostatitis like symptoms. Therefore, in the future, we should pay more attention to patients with prostatitis-like symptoms, targeted immunotherapy.
【学位授予单位】：广西医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R697.33

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