前列金丹联合坦索罗辛治疗湿热瘀阻型良性前列腺增生症的临床观察

发布时间：2018-05-14 14:51

本文选题：坦索罗辛 + 前列金丹片　；参考：《山东中医药大学》2014年硕士论文

【摘要】：目的：本课题选用前列金丹片联合盐酸坦索罗辛缓释胶囊治疗良性前列腺增生症，观察其对证候评分、国际前列腺症状评分的影响，探讨前列金丹片联合盐酸坦索罗辛缓释胶囊应用的临床疗效及安全性。方法：将临床诊断为湿热瘀阻型良性前列腺增生症的老年患者60例随机分为2组，其中单纯西药组30例，口服盐酸坦索罗辛缓释胶囊0.2mg，QD；联合用药组30例，联合服用盐酸坦索罗辛缓释胶囊0.2mg QD和前列金丹片3.24g，TID，两组均观察12个月。分别观察两组的中医证候评分、国际前列腺症状评分、生活质量评分、残余尿量、前列腺体积、肝肾功能、血常规、前列腺特异抗原（PSA）、尿常规等的变化，进行统计分析，判断疗效及安全性。结果：临床观察发现，，两组用药均能改善患者的症状，提高生活质量，减少残余尿量，降低中医证候评分、IPSS评分。两组间比较，联合用药组降低IPSS评分、中医证候评分效果优于单纯西药组。两组患者的血常规、尿常规、大便常规、前列腺体积、前列腺抗原、肝功能、肾功能无明显变化。两组间比较不良反应发生率无明显差异。结论：临床观察结果表明，前列金丹片联合盐酸坦索罗辛缓释胶囊对于IPSS评分、中医证候评分的影响明显优于单用盐酸坦索罗辛缓释胶囊，具有良好的临床疗效及安全性，为良性前列腺增生症治疗选择提供依据。
[Abstract]:Objective: to study the effect of Qianlie Jindan tablet combined with Tansulosin hydrochloride sustained-release capsule on benign prostatic hyperplasia (BPH) and to observe its effect on syndrome score and international prostatic symptom score. Objective: to investigate the clinical efficacy and safety of Qianlianjindan tablet combined with tansoloxin hydrochloride sustained-release capsule. Methods: sixty elderly patients with damp-heat stasis type benign prostatic hyperplasia were randomly divided into two groups: the western medicine group (n = 30) and the combination group (n = 30). Tansoloxine hydrochloride sustained release capsule (0.2mg QD) and Qianlie Jindan tablet (3.24 g / TID) were used in both groups for 12 months. The changes of TCM syndrome score, international prostate symptom score, quality of life score, residual urine volume, prostate volume, liver and kidney function, blood routine, prostate specific antigen (PSAA) and urine routine were observed and analyzed statistically. To judge the efficacy and safety. Results: the clinical observation showed that both groups could improve the symptoms, improve the quality of life, reduce the residual urine volume, and reduce the TCM syndrome score and IPSS score. Compared with the two groups, the combined drug group reduced the IPSS score, and the TCM syndrome score was better than that of the western medicine group. The blood routine, urine routine, stool routine, prostate volume, prostate antigen, liver function and renal function were not significantly changed in both groups. There was no significant difference in the incidence of adverse reactions between the two groups. Conclusion: the clinical observation results show that the effect of Qianliejindan tablet combined with Tansoloxin Hydrochloride sustained release capsule on IPSS score and TCM syndrome score is obviously superior to that of Tansoloxin Hydrochloride sustained-release capsule alone. It has good clinical efficacy and safety. To provide the basis for the treatment of benign prostatic hyperplasia.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R697.3

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