血清肝细胞生长因子（HGF）水平与上尿路结石的相关性研究

发布时间：2018-05-15 09:19

本文选题：HGF + 上尿路结石　；参考：《山西医科大学》2017年硕士论文

【摘要】：目的:通过定量测定上尿路结石患者血清中HGF浓度与正常人血清中HGF浓度的差异,结合患者结石成分、血生化结果、年龄、性别等进行统计学分析,探讨泌尿系结石形成的原因及HGF在泌尿系结石预防中的作用。方法:选取符合条件的结石患者80例,并选取同期生物学特征相似的正常人20例。收集患者临床资料、术后结石标本以及清晨空腹静脉血标本,离心后保存。结石成分用红外光谱结石分析仪分析,血清中的HGF水平用ELISA法测定,数据用SPSS17.0软件进行分析。结果:1、实验组中男性51例(63.8%),女性29例(36.3%),年龄范围21-56岁,平均年龄43.7±8.84岁。对照组男性12例(60%),女性8例(40)%,年龄范围在20-55岁,平均年龄39.40±9.40岁。实验组与对照组在年龄及性别方面无差异(P0.05)。2、实验组中草酸钙结石(主要为二水草酸钙和一水草酸钙)47例(58.8%),混合结石(主要为草酸钙与碳酸磷灰石)23例(28.8%),尿酸氨结石5例(6.3%),六水磷酸氨镁结石5例(6.3%)。3、实验组与对照组相比,血尿酸浓度、血钾浓度、血钠浓度、血镁浓度、血磷浓度、血钙浓度两两比较均无明显差异(P0.05)。4、实验组患者血清甘油三酯浓度与对照组病例血清甘油三酯浓度(相比明显升高(P0.05)。5.实验组患者血清胆固醇浓度与对照组病例血清胆固醇浓度相比有显著性差异(P0.05)。6、实验组血清HGF浓度与对照组血清HGF浓度相比明显降低(P0.05)。7、实验组中男性结石患者HGF浓度与女性结石患者HGF浓度相比无明显差异(P0.05)8、草酸钙结石、混合结石、六水磷酸镁铵结石及尿酸氨结石组血清HGF浓度两两比较差异不明显(P0.05)。9、对实验组血清HGF浓度与年龄进行线性相关分析结果提示血清HGF浓度与年龄无明显相关性(P0.05)结论:泌尿系结石患者血清中HGF浓度明显偏低,降低程度与结石类型无相关性;HGF的降低参与上尿路结石的形成;血清HGF的浓度与年龄、性别等无明显相关性。
[Abstract]:Objective: to measure the difference of serum HGF concentration between upper urinary tract stone patients and normal people, and to analyze the composition of stone, blood biochemical results, age, sex and so on. To explore the causes of urinary calculi and the role of HGF in the prevention of urolithiasis. Methods: 80 patients with lithiasis and 20 normal subjects with similar biological characteristics were selected. The clinical data, postoperative stone specimens and early morning fasting venous blood samples were collected and preserved after centrifugation. The HGF level in serum was determined by ELISA method, and the data was analyzed by SPSS17.0 software. Results in the experimental group, there were 51 males (63.8%) and 29 females (36.3%). The average age was 43.7 卤8.84 years (21-56 years). The control group consisted of 12 males and 8 females, aged 20-55 years, with an average age of 39.40 卤9.40 years. There was no difference in age and sex between the experimental group and the control group (P 0.05. 2). Calcium oxalate calculi (mainly calcium oxalate dihydrate and calcium oxalate monohydrate in 47 cases) and mixed stones (mainly calcium oxalate and carbonate apatite in 23 cases) were found in the experimental group. There were 5 cases of lithiasis, 5 cases of magnesium phosphate hexahydrate stone, and 5 cases of magnesium phosphate hexahydrate stone. The experimental group was compared with the control group. There was no significant difference in serum uric acid concentration, serum potassium concentration, serum sodium concentration, serum magnesium concentration, blood phosphorus concentration and serum calcium concentration. There was no significant difference in serum triglyceride concentration between the experimental group and the control group. There was significant difference in serum cholesterol concentration between the experimental group and the control group (P0.05. 6). Compared with the control group, the concentration of HGF in the serum of the experimental group was significantly lower than that of the control group. The concentration of HGF in the male calculi in the experimental group was significantly lower than that in the control group. There was no significant difference in HGF concentration between female and female stone patients (P 0.05), calcium oxalate stone, calcium oxalate stone, Mixed stones, There was no significant difference in serum HGF concentration between ammonium magnesium phosphate hexahydrate stone group and uric acid ammonia stone group. The linear correlation analysis between serum HGF concentration and age in experimental group showed that there was no significant correlation between serum HGF concentration and age (P0.05). Conclusion: the concentration of HGF in the serum of patients with urinary calculi is obviously low. There was no correlation between the degree of reduction and the type of calculi. There was no significant correlation between the concentration of serum HGF and age, sex, etc.
【学位授予单位】：山西医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R691.4

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