维持性透析患者颈动脉斑块形成的影响因素及与心血管疾病的关系

发布时间：2018-05-17 03:11

本文选题：维持性透析 + 颈动脉斑块　；参考：《实用医学杂志》2017年10期

【摘要】：目的:通过对维持性透析患者颈动脉斑块形成的影响因素进行分析并探讨与心血管疾病(CVD)的关系。方法:对病情稳定的52例腹膜透析患者及46例血液透析患者行颈动脉彩超,检测双侧颈动脉内膜中层厚度(IMT)及颈动脉斑块,并记录相关临床指标及CVD情况。对透析模式、颈动脉斑块情况、合并CVD分别进行分组,并行统计学分析。结果:与无颈动脉斑块组患者相比,有颈动脉斑块组患者的年龄、男性比例、高血压人数、糖尿病人数、血尿酸、血糖水平、心血管疾病发生率较高,白蛋白水平较低(P0.05);二分类Logistic回归分析示对颈动脉斑块形成有显著影响的变量是高血压、白蛋白和尿酸;斑块主要分布在颈总动脉(CCA)及颈动脉分叉部(BIF),且合并CVD组的数量较多(P0.01)。结论:维持性透析患者颈动脉斑块形成与CVD的发生密切相关。高血压、白蛋白和尿酸是颈动脉斑块形成的危险因素,因此透析患者除了维持血压、改善营养外,控制尿酸水平也非常重要。
[Abstract]:Objective: to investigate the relationship between carotid plaque formation and cardiovascular disease (CVD) in maintenance dialysis patients. Methods: carotid color Doppler ultrasound was performed in 52 patients with stable peritoneal dialysis and 46 patients with hemodialysis. The carotid intima-media thickness (IMT) and carotid plaque were measured, and the clinical indexes and CVD were recorded. Dialysis pattern, carotid plaque, combined with CVD were divided into groups, and statistical analysis was carried out. Results: age, male ratio, number of hypertension, diabetes mellitus, uric acid, blood glucose level, incidence of cardiovascular disease were higher in patients with carotid plaques than in those without carotid plaques. Logistic regression analysis showed that hypertension, albumin and uric acid were the most important factors in carotid plaque formation, the plaques were mainly distributed in the common carotid artery (CCAA) and the bifurcation of carotid artery (BIFA), and the number of patients with CVD was higher than that of CVD group (P 0.01). Conclusion: carotid plaque formation in maintenance dialysis patients is closely related to the occurrence of CVD. Hypertension, albumin and uric acid are risk factors for carotid plaque formation, so it is also important to control uric acid levels in dialysis patients in addition to maintaining blood pressure and improving nutrition.
【作者单位】：广州医科大学附属第二医院肾内科;
【基金】：广东省科技计划项目(编号:2011B031800307)
【分类号】：R54;R692.5

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