手术前炎症指标与输尿管癌的病理分期和分级的关系

发布时间：2018-05-19 00:22

本文选题：输尿管癌 + 中性粒细胞/淋巴细胞比值　；参考：《延边大学》2014年硕士论文

【摘要】：目的：探讨手术前炎症指标和血清白蛋白与输尿管癌的病理TNM分期和分级的相关性。方法：回顾性分析了经手术后病理确诊的,具有完整临床病理资料的输尿管癌78例的术前炎症指标,采用血小板/淋巴细胞比值(PLR150：1)、中性粒细胞/淋巴细胞比值(NLR2.5：1),血清白蛋白(37g/L)为分界值,分析3种指标与输尿管癌的TNM分期和病理分级的相关性。结果：输尿管癌的T1、T2(a)、T2(b)和T3期分期中NLR2.5：1各为17.65%,36.84%,47.06%和73.91%(P=0.005)；PLR150：1各为5.58%,36.84%,52.96%和56.52%(P=0.009)。低血清白蛋白血症在输尿管癌T1、T2和T3分期中各为35.29%,42.1%和60.87%。在输尿管癌的组织学低级别和高级别中PLR150：1各为22.5%和50.0%(P=0.008),NLR2.5：1各为32.5%和60%(P=0.010)。结论：术前炎症指标NLR、PLR和血清白蛋白与输尿管癌的TNM分期和病理分级密切相关,基于炎症指标和病理分级和分期的模型对临床实践有用。
[Abstract]:Objective: to investigate the correlation between preoperation inflammatory index and serum albumin and pathological TNM stage and grade of ureteral carcinoma. Methods: the preoperative inflammatory indexes of 78 cases of ureteral carcinoma confirmed by operation and pathology were analyzed retrospectively. The platelet / lymphocyte ratio (PLR 150: 1), neutrophil / lymphocyte ratio (NLR 2.5: 1) and serum albumin (37 g / L) were used to analyze the correlation between the three indexes and the TNM stage and pathological grade of ureteral carcinoma. Results: the NLR2.5:1 in stage T _ 1, T _ 2, T _ 2 and T _ 3 of ureteral carcinoma was 17.65% and 36.84%, 47.06% and 73.91%, respectively, and the PLR150: 1 was 5.588.84%, 52.96% and 56.52%, respectively. The percentage of hypoalbuminemia in T _ 1 T _ 2 and T _ 3 staging of ureteral carcinoma was 35.29.1% and 60.87%, respectively. In the low grade and high grade of ureteral carcinoma, the PLR150:1 were 22. 5% and 50. 0% respectively. NLR 2. 5: 1 was 32.5% and 60% respectively. Conclusion: the TNM staging and pathological grade of ureteral carcinoma are closely related to the preoperative inflammatory markers NLRL PLR and serum albumin. The model based on inflammation index and pathological grade and staging is useful in clinical practice.
【学位授予单位】：延边大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R737.13

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