尿素通道蛋白B在人膀胱癌组织中的表达及其临床意义

发布时间：2018-05-20 02:13

本文选题：膀胱肿瘤 + 尿素通道蛋白B　；参考：《吉林大学学报(医学版)》2017年04期

【摘要】：目的:检测膀胱癌患者肿瘤组织和正常膀胱黏膜组织中尿素通道蛋白B(UT-B)的表达,阐明其在膀胱癌组织中表达的临床意义。方法:收集临床膀胱癌患者术后石蜡包埋标本52例,以正常膀胱黏膜组织15例作为对照,采用免疫组织化学方法检测UT-B蛋白阳性表达率,分析UT-B蛋白阳性表达率在膀胱癌组织和正常膀胱黏膜表达的差异以及其与患者临床病理参数的关联。结果:UT-B蛋白在膀胱癌组织中低表达,阳性表达率为44.2%;在正常膀胱黏膜组织中高表达,阳性表达率为93.3%,2组UT-B蛋白阳性表达率比较差异有统计学意义(P=0.001)。膀胱癌组织中UT-B蛋白的阳性表达率随肿瘤组织分级的增高而逐渐降低,不同分级间比较差异有统计学意义(P=0.010)。膀胱癌组织中UT-B蛋白在非肌层浸润期(Ta+T1)的阳性表达率明显高于肌层浸润期(T2+T3),组间比较差异有统计学意义(P=0.014)。结论:UT-B蛋白的表达降低或缺失可能促进了膀胱癌的发生发展和侵袭。
[Abstract]:Aim: to detect the expression of urea channel protein (UT-B) in tumor tissues and normal bladder mucosa of patients with bladder cancer and to elucidate its clinical significance. Methods: 52 cases of postoperative paraffin embedded specimens of bladder cancer and 15 cases of normal bladder mucosa were collected. The positive rate of UT-B protein was detected by immunohistochemical method. To analyze the difference of positive expression rate of UT-B protein between bladder cancer and normal bladder mucosa and its correlation with clinicopathologic parameters. Results there was a significant difference in the positive expression rate of UT-B protein between the two groups (P < 0.01), and the positive expression rate of UT-B protein in bladder cancer was 44.22.The positive expression rate of UT-B protein was 93.3% in normal bladder mucosa and 93.3% in the normal bladder mucosa, and there was significant difference between the two groups in the positive expression rate of UT-B protein in bladder cancer tissue and in normal bladder mucosa tissue. The positive expression rate of UT-B protein in bladder cancer tissues decreased gradually with the increase of tumor grade, and the difference between different grades was statistically significant. The positive expression rate of UT-B protein in non-myometrial infiltrating phase was significantly higher than that in T 2T _ 3 (P < 0.014). Conclusion the decreased or absent expression of UT-B protein may promote the development and invasion of bladder cancer.
【作者单位】：北华大学基础医学院免疫学教研室;吉林大学药学院;北京大学基础医学院药理学系;
【基金】：吉林省科技厅基础研究计划项目资助课题(20150101128JC) 吉林省教育厅项目资助课题(2013193)
【分类号】：R737.14

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