134例前列腺癌患者的临床分析

发布时间：2018-05-22 20:15

本文选题：前列腺癌 + 诊断　；参考：《南昌大学》2014年硕士论文

【摘要】：目的：回顾我院已追踪随访134例前列腺癌患者的临床资料，总结我科前列腺癌的诊断和治疗现状。方法：收集南昌大学第二附属医院自2008年8月至2013年8月收治的前列腺癌患者的临床资料，并对临床资料完整且能够随访到的134例患者的临床资料及随访资料进行统计和分析，这些资料主要有患者的年龄、就诊的主要原因、辅助检查情况、临床分期、病理分级、治疗情况、治疗后排尿及生存情况。结果：本组前列腺癌病例共有134例，年龄范围为54~87岁，平均年龄72.4±4.4岁；因下尿路症状如排尿困难、尿频、尿急、尿痛、血尿、尿潴留等症状就诊有104例，占77.3%；血清PSA升高者124例，占92.5%；临床分期C+D期占55.2%（74/134）；病理分级分化差或未分化的有66例，占82.5%（66/80）；行前列腺癌根治术的为15例，占11.2%，行手术去势+比卡鲁胺/氟他胺治疗的有105例，占78.4%；行前列腺癌根治术的患者中有1例术后出现严重的尿失禁，行手术去势+比卡鲁胺/氟他胺治疗的患者排尿情况绝大部分都有不同程度改善（102/105）；行手术去势+比卡鲁胺/氟他胺治疗的105例患者中，死亡9例，死亡患者平均生存23.2个月。结论：前列腺癌就诊患者多为高龄患者；就诊的主要原因多为下尿路梗阻症状；就诊时多为中晚期患者，病理分级多为分化差或未分化；PSA的对前列腺癌的敏感性较好，，目前PSA在前列腺癌的诊断中仍占据重要地位；内分泌治疗在国内前列腺癌的治疗中仍占有较高的比例，手术去势联合抗雄激素药物治疗患者的排尿症状都有不同程度的改善。
[Abstract]:Objective: The clinical data of 134 cases of prostate cancer in our hospital were reviewed, and the diagnosis and treatment of prostate cancer in our department were summarized. Methods: To collect the clinical data of patients with prostate cancer treated in the second affiliated Hospital of Nanchang University from August 2008 to August 2013, and to analyze the clinical data and follow-up data of 134 patients with complete clinical data, These data mainly include the patient's age, the main reason of seeing a doctor, auxiliary examination, clinical stage, pathological grading, treatment, urination and survival after treatment. Results: There were 134 cases of prostate cancer, with an average age of 72.4 卤4.4 years, with an average age of 72.4 卤4.4 years. 104 cases (77.3%) were treated for symptoms of lower urinary tract such as dysuria, frequency of urination, urgency, pain, hematuria, retention of urine, etc. 92.5%; clinical stage C D accounted for 55.2% / 134%; pathological grade was poor or undifferentiated in 66 cases (82.566 / 80%); radical prostatectomy was performed in 15 cases (11.2%); Ovariectomy was performed in 105 cases compared with Carous / flutamide. One of the patients undergoing radical prostatectomy had severe urinary incontinence after surgery. In most of the patients who underwent castration compared with Carous / flutamide, the urination status of the patients was improved to some extent, and 9 of the 105 patients treated with Carous / flutamide had died, and the average survival of the dead patients was 23.2 months. Conclusion: Most of the patients with prostate cancer were elderly patients, the main reason was lower urinary tract obstruction, most of them were middle or late stage patients, and the pathological grade was poor differentiation or undifferentiated PSA, and the sensitivity of prostate cancer was better. At present, PSA still plays an important role in the diagnosis of prostate cancer, endocrine therapy still occupies a high proportion in the treatment of prostate cancer in China, and the urination symptoms of patients treated with castration combined with anti-androgen drugs have been improved in varying degrees.
【学位授予单位】：南昌大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R737.25

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