血清ALP、ICTP、sTf水平及癌组织BMP表达对前列腺癌骨转移的预测价值

发布时间：2018-05-23 21:51

本文选题：前列腺癌 + 骨转移　；参考：《山东医药》2017年48期

【摘要】：目的探讨血清碱性磷酸酶(ALP)、Ⅰ型胶原交联羧基端肽(ICTP)、可溶性转铁蛋白受体(s TfR)水平及癌组织骨形态发生蛋白(BMP)表达变化对前列腺癌骨转移的预测价值。方法研究对象为92例行手术治疗的前列腺癌患者,术后病理检查证实诊断。入院后均采用ELISA法检测血清ALP、ICTP、s TfR,采用免疫组化法检测癌组织BMP-2、BMP-4、BMP-7。术后随访2年,随访期间发生骨转移(经病理学证实)33例(骨转移组),未发生骨转移59例(无骨转移组)。回顾性分析转移组与未转移组入院时上述指标水平差异及相关性。结果骨转移组血清ALP、ICTP水平均高于无骨转移组,血清s TfR水平低于无骨转移组,组间比较P均0.01。骨转移组癌组织BMP-2、BMP-4、BMP-7免疫组化总评分均高于无骨转移组(P均0.05)。前列腺骨转移患者血清ALP、ICTP水平与癌组织BMP-2、BMP-4、BMP-7免疫组化总评分均呈正相关(P均0.05),血清s TfR水平与癌组织BMP-2、BMP-4、BMP-7免疫组化总评分均呈负相关(P均0.05)。结论前列腺癌患者血清ALP、ICTP水平升高,血清s TfR水平降低,癌组织BMP-2、BMP-4、BMP-7表达增加者发生骨转移的可能性更大。
[Abstract]:Objective to investigate the predictive value of serum alkaline phosphatase (ALP), type I collagen cross-linked carboxyl terminal peptide (ICTPN), soluble transferrin receptor (TfR) and the expression of bone morphogenetic protein (BMP) in prostate cancer in predicting bone metastasis of prostate cancer. Methods 92 patients with prostate cancer were treated surgically. The diagnosis was confirmed by postoperative pathological examination. ELISA method was used to detect serum ALPT-PfRand the immunohistochemical method was used to detect BMP-4 and BMP-7 in cancer tissue. Bone metastases were found in 33 cases (bone metastasis group) and no bone metastasis in 59 cases (no bone metastasis group). The difference and correlation of the above indexes between the metastatic group and the non-metastatic group were analyzed retrospectively. Results the levels of serum ALP TfR in bone metastasis group were higher than those in no bone metastasis group, and the serum s TfR level was lower than that in bone metastasis group (P < 0.01). The total immunohistochemical scores of BMP-2BMP-4 and BMP-7 in bone metastasis group were higher than those in bone metastasis group (P < 0.05). There was a positive correlation between the level of serum ALP TfR and the total immunohistochemical score of BMP-4, BMP-4 and BMP-7 in patients with bone metastasis of prostate (P < 0.05). There was a negative correlation between the level of serum s TfR and the total immunohistochemical score of BMP-2BMP-4 and BMP-7 in cancer tissue (P < 0.05). Conclusion in prostate cancer patients, the level of serum ALP TfR is higher and the level of serum s TfR is lower. The higher expression of BMP-2, BMP-4 and BMP-7 is more likely to develop bone metastasis in patients with prostate cancer.
【作者单位】：河南省中医院;
【基金】：河南省中医药科学研究专项项目(2013ZY02045)
【分类号】：R737.25

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