糖调节受损伴良性前列腺增生患者血清IGF-1、IGFBP-3的水平

发布时间：2018-05-24 06:48

本文选题：糖调节受损 + 良性前列腺增生　；参考：《实用医学杂志》2016年04期

【摘要】：目的:检测糖调节受损(IGR)合并良性前列腺增生(BPH)患者胰岛素水平、胰岛素生长因子-1(IGF-1)、胰岛素生长因子结合蛋白-3(IGFBP-3)等指标,旨在探讨IGF-1、IGFBP-3等指标与前列腺体积(PV)的相关性。方法 :选取年龄≥50岁的BPH患者109例,根据OGTT结果分为糖耐量正常(NGT)组56例、空腹血糖受损(IFG)组14例及糖耐量减低(IGT)组39例;测量各组人群常规生化指标、前列腺增生指标以及血清IGF-1、IGFBP-3浓度等。结果:3组患者血脂、同型半胱氨酸、胱抑素C、空腹胰岛素(FINS)、糖化血红蛋白、IGF-1、IGFBP-3比较均无统计学差异(P0.05);3组患者PV、前列腺特异抗原、生活质量评分、国际前列腺症状评分比较无统计学差异(P0.05)。IFG组空腹血糖、胰岛素抵抗指数(HOMA-IR)高于NGT组(P′0.017)和IGT组(P′0.017);IGT组2 h血糖、2 h胰岛素高于NGT组(P′0.017)及IFG组(P′0.017);多元逐步回归分析,PV与FINS呈正相关,与IGF-1、IGFBP-3无关。结论:高血清胰岛素水平是IGR合并BPH患者前列腺增生进展的危险因素,血清IGF-1、IGFBP-3与BPH无相关性,需进一步研究阐明IGF-1、IGFBP-3在BPH的作用。
[Abstract]:Objective: to investigate the correlation between IGF-1IGFBP-3 and prostatic volume (PVV) in patients with impaired glucose regulation (IGR) and benign prostatic hyperplasia (BPH). Methods: 109 BPH patients aged more than 50 years were divided into normal glucose tolerance group (n = 56), fasting blood glucose impaired group (n = 14) and impaired glucose tolerance group (n = 39) according to the results of OGTT. Prostatic hyperplasia index and serum IGF-1 IGFBP-3 concentration. Results there was no significant difference in blood lipids, homocysteine, cystatin C, fasting insulin and IGF-1IGFBP-3 between the three groups. There was no statistical difference in the international prostate symptom score (P 0.05). The fasting blood glucose in the IFG group was higher than that in the control group. Insulin resistance index (HOMA-IRI) was higher than that of NGT group (P 0.017), IGT group (P 0.017) and IGT group (P < 0.017) and IFG group (P < 0.017). Multivariate stepwise regression analysis showed that PV was positively correlated with FINS, but had no correlation with IGF-1IGFBP-3. Conclusion: high serum insulin level is a risk factor for the progression of BPH in IGR patients with BPH. There is no correlation between IGF-1IGFBP-3 and BPH. It is necessary to further study the role of IGF-1IGFBP-3 in BPH.
【作者单位】：承德医学院附属医院老年病科;承德医学院附属医院检验科;
【基金】：河北省医学科学研究重点课题计划(编号:ZL20140234) 2016年政府资助临床医学优秀人才培养和基础课题研究项目(编号:361008)
【分类号】：R697.3

【相似文献】