慢性心肾综合征患者外周血TnI、NT-proBNP、H-FABP及MYO水平观察

发布时间：2018-05-25 22:15

本文选题：心肾综合征 + 慢性肾脏病　；参考：《山东医药》2017年07期

【摘要】：目的观察慢性心肾综合征患者外周血肌钙蛋白Ⅰ(Tn I)、N末端脑钠肽原(NT-proBNP)、心脏脂肪酸结合蛋白(H-FABP)、肌红蛋白(MYO)水平变化,寻找慢性心肾综合征患者早期心脏损伤的生物标志物。方法 83例CKD患者,分为CKD 1~2期非CRS者28例(1组)、CKD 3~4期非CRS者14例(2组)、CKD 1~2期CRS者19例(3组)、CKD 3~4期CRS者22例(4组)。另选同期我院20例健康体检者为对照组。采集各组空腹静脉血,检测各组外周血Tn I、NT-proBNP、MYO、H-FABP水平,计算H-FABP与MYO的浓度比值(F/M)。检测各组肾功能及相关生化指标,观测各组心脏结构及功能。结果对照组、1、2、3、4组外周血Tn I比较,P均0.05;对照组、1、2、3、4组外周血NT-proBNP分别为20、36、159、249、372 pg/m L,组间比较,P均0.05;2、3、4组MYO、H-FABP均高于1组及对照组,且2组均高于1组,4组均高于3组(P0.05);F/M在3、4高于1、2组及对照组(P0.05)。结论慢性心肾综合征患者外周血NT-proBNP、H-FABP、MYO水平升高,F/M升高。F/M受GFR的影响最小,可作为慢性心肾综合征的早期诊断指标。
[Abstract]:Objective to observe the changes of levels of troponin I in peripheral blood of patients with chronic cardiorenal syndrome (CHS), and to find out the biomarkers of early cardiac injury in patients with chronic cardiorenal syndrome (CHS). The levels of NT-proBNPP, cardiac fatty acid binding protein (HFABPN) and myoglobin MYO (myoglobin) in patients with chronic cardiorenal syndrome (CHS) were observed. Methods Eighty-three patients with CKD were divided into two groups (n = 28) with CKD 1 / 2 stage non CRS (n = 28), group B (n = 14) with non-CRS stage C / D (n = 14) and group B (n = 19) with CRS of stage 1 / 2 (n = 19) and group C (n = 22) with CRS at stage 3 / 4 (n = 22). In the same period, 20 healthy persons in our hospital were selected as the control group. Fasting venous blood was collected from each group. The levels of TNI NT-proBNPMYOOOH-FABP in peripheral blood of each group were measured, and the ratio of H-FABP to MYO was calculated. Renal function and related biochemical indexes were detected and cardiac structure and function were observed in each group. Results the levels of TnI in peripheral blood of the control group were 0.05, the NT-proBNP of the control group were 20 / 36159249 / 372 pg/m / L, respectively, and the levels of NT-proBNP in the control group were higher than those in the control group (P < 0.05) and the control group (P < 0.05), respectively, and were significantly higher than those in the control group (P < 0.05) and the control group (P < 0.05) respectively, and the levels of NT-proBNP in the control group were significantly higher than those in the control group (P < 0.05). Both groups were higher than those in group 1 and group 4 were higher than those in group 3 (P 0.05N / M) than group 1 (P 0.05) and control group (P 0.05). Conclusion the level of NT-proBNPH-FABPMYO in peripheral blood of patients with chronic cardiorenal syndrome is the least affected by GFR. It can be used as an early diagnostic index of chronic cardiorenal syndrome.
【作者单位】：徐州医科大学附属医院;
【基金】：国家自然基金资助项目(81270769) 江苏省十二五医学重点人才项目(RC2011116) 江苏省自然科学基金资助项目(BK20161172) 江苏省六大人才高峰项目(2010-WS043) 新疆奎屯市基金资助项目(201134)
【分类号】：R541;R692

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