前列舒通联合喹诺酮类抗菌药物治疗慢性前列腺炎疗效与安全性的Meta分析

发布时间：2018-05-27 07:16

  本文选题：前列舒通胶囊 + 喹诺酮类抗菌药物　； 参考：《中国药房》2016年06期

【摘要】：目的:系统评价前列舒通胶囊联合喹诺酮类抗菌药物治疗慢性前列腺炎的疗效与安全性,以为临床提供循证参考。方法:计算机检索Pub Med、EMBase、Cochrane图书馆、中国生物医学文摘数据库、相关期刊论文、中文科技期刊数据库和万方数据库,收集前列舒通胶囊联合喹诺酮类抗菌药物(试验组)对比单用喹诺酮类抗菌药物(对照组)治疗慢性前列腺炎的随机对照试验(RCT),对符合纳入标准的临床研究进行资料提取,并采用改良后的Jadad量表进行质量评价,采用Rev Man 5.3统计软件进行Meta分析。结果:共纳入16项RCT,合计2 368例患者。Meta分析结果显示,试验组患者的总有效率[RR=1.56,95%CI(1.29,1.88),P0.001]、美国国立卫生研究院慢性前列腺炎症状指数评分[MD=-6.97,95%CI(-8.67,-5.26),P0.001]、疼痛症状评分[MD=-3.18,95%CI(-3.92,-2.44),P0.001]、排尿障碍评分[MD=-1.62,95%CI(-1.85,-1.38),P0.001]、生活质量评分[MD=-2.16,95%CI(-2.89,-1.43),P0.001]、前列腺液白细胞计数[MD=-8.90,95%CI(-11.79,-6.02),P0.001]和复发率[RR=0.22,95%CI(0.12,0.42),P0.001]均显著优于对照组,差异均有统计学意义;两组患者不良反应发生率比较,差异无统计学意义[RR=0.49,95%CI(0.11,2.13),P=0.34]。结论:前列舒通胶囊联合喹诺酮类抗菌药物治疗慢性前列腺炎的疗效优于单用喹诺酮类抗菌药物,安全性相当。
[Abstract]:Objective: to evaluate the efficacy and safety of Qianlieshutong capsule combined with quinolones in the treatment of chronic prostatitis. Methods: a computerized search was conducted for the Pub Medsite EMBase Cochrane Library, the Chinese Biomedical Abstract Database, the full text Database of Chinese Journals, the Chinese Sci-tech Journals Database and the Wanfang Database. To collect Qianlieshutong capsule combined with quinolones antibiotics (test group) as compared with the control group treated with quinolones antibiotics (control group) in a randomized controlled trial (RCTT) for chronic prostatitis, and to extract the data of clinical studies that met the inclusion criteria. The improved Jadad scale was used to evaluate the quality and the Rev Man 5.3 software was used for Meta analysis. Results: a total of 16 RCTs were included. 璇曢獙缁勬偅鑰呯殑鎬绘湁鏁堢巼[RR=1.56,95%CI(1.29,1.88),P0.001],缇庡浗鍥界珛鍗�鐢熺爺绌堕櫌鎱㈡�у墠鍒楄吅鐐庣棁鐘舵寚鏁拌瘎鍒哰MD=-6.97,95%CI(-8.67,-5.26),P0.001],鐤肩棝鐥囩姸璇勫垎[MD=-3.18,95%CI(-3.92,-2.44),P0.001],鎺掑翱闅滅�嶈瘎鍒哰MD=-1.62,95%CI(-1.85,-1.38),P0.001],鐢熸椿璐ㄩ噺璇勫垎[MD=-2.16,95%CI(-2.89,-1.43),P0.001],鍓嶅垪鑵烘恫鐧界粏鑳炶�℃暟[MD=-8.90,95%CI(-11.79,-6.02),P0.001]鍜屽�嶅彂鐜嘯RR=0.22,95%CI(0.12,0.42),P0.001]鍧，

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