血清前列腺特异性抗原、前列腺特异性抗原密度和高迁移率族蛋白B1诊断老年前列腺癌的价值

发布时间：2018-05-29 08:08

本文选题：前列腺特异性抗原 + 前列腺特异性抗原密度　；参考：《中国老年学杂志》2017年20期

【摘要】：目的探讨血清前列腺特异性抗原(PSA)、前列腺特异性抗原密度(PSAD)和高迁移率族蛋白(HMG)B1用于老年前列腺癌的诊断价值。方法选择老年前列腺癌患者69例(前列腺癌组)、同期老年前列腺增生患者60例(前列腺增生组)及健康体检老年男性51例作为对照组。所有研究对象于清晨空腹采集外周静脉血,分离血清,采用酶联免疫吸附法(ELISA)测定血清PSA、PSAD和HMGB1含量。结果前列腺癌组血清PSA、PSAD和HMGB1水平明显高于前列腺增生组和对照组(前列腺增生组:t=29.674、25.212、23.665,对照组:t=35.654、36.293、30.286,均P0.05);前列腺增生组血清PSA、PSAD和HMGB1水平明显高于对照组(t=27.203、22.603、19.910,均P0.05)。PSA+PSAD+HMGB1联合诊断前列腺癌敏感度和特异度明显高于PSA、PSAD、HMGB1单独检测。PSA与PSAD、PSAD与HMGB1、PSA与HMGB1均呈正相关。结论老年前列腺癌患者血清PSA、PSAD、HMGB1水平明显升高,PSA+PSAD+HMGB1联合诊断具有较高的敏感度和特异度。
[Abstract]:Objective to investigate the diagnostic value of serum prostate specific antigen (PSA), prostate specific antigen density (PSA) and high mobility group protein (HMGN B1) in the diagnosis of prostate cancer in elderly patients. Methods Sixty-nine elderly patients with prostate cancer (prostate cancer group), 60 elderly patients with prostatic hyperplasia (BPH group) and 51 healthy aged men (control group) were selected as control group. All subjects collected peripheral venous blood on an empty stomach in the morning and isolated serum. The serum levels of PSAD and HMGB1 were determined by enzyme-linked immunosorbent assay (Elisa). Results the levels of serum PSAD and HMGB1 in prostate cancer group were significantly higher than those in benign prostatic hyperplasia group and control group (BPH group, BPH group, n = 29.674, 25.21212, 23.665, control group, n = 36.2934, 30.286, respectively, PSA-PSAD and HMGB1 levels in prostate hyperplasia group were significantly higher than those in control group, the levels of serum PSAD and HMGB1 in benign prostatic hyperplasia group were significantly higher than those in the control group, which were 27.2033P, 22.603, 19.910, respectively. The sensitivity and specificity of prostate cancer were significantly higher than those of PSAD, PSADG, PSAD, HMGB1, PSAD and HMGB1, respectively. There was a positive correlation between PSA and HMGB1. Conclusion the serum level of PSA-PSADG-HMGB1 in the elderly patients with prostate cancer is significantly higher than that in the control group, and it has a high sensitivity and specificity in the combined diagnosis of PSA and PSADGB1.
【作者单位】：温州医科大学附属台州医院泌尿外科;
【分类号】：R737.25

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