回顾性分析供肾合并单纯性肾囊肿对活休肾移植预后的影响

发布时间：2018-05-31 11:30

本文选题：单纯性肾囊肿 + 供肾　；参考：《浙江大学》2017年硕士论文

【摘要】：目的单纯性肾囊肿可能是慢性肾病的早期表现。本研究旨在探讨供肾合并单纯性肾囊肿是否会对活体肾移植受体的预后产生影响。方法回顾性分析2007年4月-2015年4月在我院肾脏病中心进行活体肾移植的716例受体与供体的资料。通过查看供体术前腹部增强CT的影像资料,发现共91例供体有单纯性肾囊肿,其中64例供体的供肾侧有肾囊肿。将这64例供肾合并囊肿的受体与供肾无合并囊肿的受体进行1:2匹配,匹配条件依次是供体性别,受体性别,供体术前血肌酐值,供/受体BSA比值,供体的年龄,受体年龄,及手术日期。分析两组受体在术后随访期内的移植肾预后情况。结果单纯性肾囊肿的发病率与供体的性别、年龄及肾小球滤过率值独立相关。根据供肾零点穿刺病理结果显示,供肾囊肿组的肾小球硬化率比供肾无囊肿组的高(P=0.040)。供肾囊肿组与无囊肿组的受体在术后第7天,6月,5年的肾小球滤过率比值分别为 80.82±26.61 vs.88.21±23.12,66.95±17.42 vs.72.15±16.42,60.92±22.17vs.68.72±14.43ml/(min·1.73m2)(P0.05)。两组在术后第 7 天,6 月的血肌酐比值分别为 112.14±48.32 vs.98.75±29.71,126.28±42.32 vs.115.05±26.35μmol/l(P0.05)。两组受体的5年移植肾/人生存率无明显差异。结论在活体肾移植中,供肾合并单纯性肾囊肿会影响移植肾早期和长期的功能。在筛选供体时,肾囊肿需作为考虑因素之一。
[Abstract]:Objective simple renal cyst may be an early manifestation of chronic nephropathy. The purpose of this study was to investigate whether donor kidney complicated with simple renal cysts may have an effect on the prognosis of renal transplant recipients in vivo. Methods from April 2007 to April 2015, 716 recipients and donors of live kidney transplantation in our renal disease center were retrospectively analyzed. A total of 91 donors were found to have simple renal cysts, of which 64 had renal cysts on the donor side. The recipients of these 64 cases were matched at 1:2 with those without cyst of donor kidney. The matching conditions were donor sex, recipient sex, serum creatinine value, donor / receptor BSA ratio, donor age and recipient age. And the date of the operation. To analyze the prognosis of renal allograft in the two groups during the follow-up period. Results the incidence of simple renal cyst was independent of donor sex, age and glomerular filtration rate. The glomerular sclerosis rate in the donor renal cyst group was higher than that in the donor renal cyst group. The ratio of glomerular filtration rate between the donor cysts group and the non-cysts group was 80.82 卤26.61 vs.88.21 卤23.12 66.95 卤17.42 vs.72.15 卤16.42 卤60.92 卤22.17vs.68.72 卤1.73 m ~ 2 (P 0.05) on the 7th day, 6th month and 5th year after operation, respectively. The serum creatinine ratio of the two groups was 112.14 卤48.32 vs.98.75 卤29.71 126.28 卤42.32 vs.115.05 卤26.35 渭 mol / L P 0.05 on the 7th day after operation. There was no significant difference in 5-year survival rate between the two groups. Conclusion donor kidney combined with simple renal cysts may affect the early and long term function of donor kidney in living donor kidney transplantation. Renal cyst should be considered as a factor in donor selection.
【学位授予单位】：浙江大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R699.2

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