血清TL1A水平与狼疮肾炎的相关性研究

发布时间：2018-06-01 09:16

本文选题：狼疮性肾炎 + 系统性红斑狼疮　；参考：《川北医学院》2017年硕士论文

【摘要】：目的:通过测定狼疮性肾炎(LN)患者血清中肿瘤坏死因子样配体1A(TL1A)的水平,探讨TL1A在LN患者的临床意义。方法:选取狼疮性肾炎患者60例作为实验组,并选择34例性别、年龄相匹配的健康者作为对照组,运用酶联免疫吸附法(ELISA)测定血清中TL1A的水平。采用t检验分析不同组血清TL1A水平差异性,采用Spearman相关性检验分析血清TL1A水平与疾病活动度、实验室指标等的相关性。结果:1.LN患者血清TL1A水平(827.80±235.84pg/ml)较健康对照组血清水平(589.26±87.31pg/ml)显著升高,差异有统计学意义(Ρ0.01)。2.LN活动组血清TL1A水平高于LN稳定组及健康对照组,差异均有统计学意义(Ρ0.01)。LN稳定组血清TL1A水平高于健康对照组,但差异无统计学意义(P㧐0.05)。3.LN患者血清TL1A水平与SLEDAI、24小时尿蛋白定量、CRP、anti-dsDNA、Anu A呈正相关;与补体3、补体4、白蛋白呈负相关;与ESR、血肌酐、C1q、抗C1q抗体水平无相关性,结论:TL1A可能参与了LN的发生与发展,LN患者血清TL1A水平升高且与疾病活动度相关,可根据其血清水平来判断病情、选择治疗方案。
[Abstract]:Objective: to investigate the clinical significance of TL1A in LN patients by measuring the level of TNF- 伪 ligand 1Atl 1A in serum of patients with lupus nephritis (LN). Methods: 60 patients with lupus nephritis were selected as experimental group and 34 healthy persons with matched sex and age as control group. Serum TL1A levels were measured by Elisa. T test was used to analyze the difference of serum TL1A level in different groups, and Spearman correlation test was used to analyze the correlation between serum TL1A level and disease activity, laboratory indexes and so on. Results 1. The serum TL1A level of LN patients was 827.80 卤235.84pg / ml, which was significantly higher than that of healthy control group (589.26 卤87.31pg / ml). The serum TL1A level in LN active group was higher than that in LN stable group and healthy control group. There was significant difference in serum TL1A level between stable group and healthy control group, but there was no significant difference between serum TL1A level and 24 hour urinary protein quantification of SLEDAI, complement 3, complement 4 and albumin. There was no correlation between the level of serum creatinine C _ 1Q and anti-C _ 1q antibody. Conclusion: TL1A may be involved in the pathogenesis and development of LN, and may be associated with the increase of serum TL1A level and disease activity, so we can judge the condition according to the serum level of LN and choose the treatment plan.
【学位授予单位】：川北医学院
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R593.242

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