自噬与肾缺血再灌注

发布时间：2018-06-02 07:12

本文选题：自噬 + 肾脏　；参考：《重庆医科大学》2014年硕士论文

【摘要】：背景：自噬是一种高度保守的细胞内调控机制，它能够对胞内蛋白及器官进行降解以维持细胞内的稳态。越来越多的证据表明，自噬在肾脏损伤,修复及衰老过程中发挥着重要作用。缺血,缺氧,毒性物质损伤,自身免疫以及氧化应激都能引发肾小管上皮细胞的自噬，并在各种肾脏疾病发生发展中产生影响。目的：综述自噬在肾脏缺血再灌注损伤中所起作用的研究进展。方法：使用计算机对PubMed、EBSCO、CNKI等数据库中1998-01/2013-06有关自噬以及肾脏缺血再灌注损伤的文章进行检索，，检索词为“autophagy, ischemia,reperfusion, kidney, renal”等，去重之后共检索出文献284篇。对文章标题、摘要、全文进行阅读筛选，去除不合格文献后，最终纳入42篇文章进行综述分析。结果与结论：自噬与凋亡相互影响，都在肾脏缺血再灌注损伤中发挥着至关重要的作用。通过对自噬的干预调控，可以影响再灌注损伤程度以及损伤后的恢复。其可能成为防治肾脏缺血再灌注损伤的一个新的作用靶点。
[Abstract]:Background : autophagy is a highly conserved intracellular regulation mechanism that can degrade intracellular proteins and organs to maintain homeostasis in cells . More and more evidence suggests that autophagy plays an important role in kidney damage , repair and aging . Ischemia , hypoxia , toxic substance damage , autoimmune , and oxidative stress can trigger autophagy of tubular epithelial cells and have an impact on the development of various renal diseases .

Objective : To review the role of autophagy in renal ischemia - reperfusion injury .

Methods : The computer was used to retrieve articles related to autophagy and renal ischemia - reperfusion injury in the databases , EBSCO , CNKI and other databases . The search term was " autophagy , ischemia , reperfusion , kidney , renal " and so on . 284 articles were retrieved . The title , abstract and full text of the article were read and screened . After the non - conforming literature was removed , 42 articles were included in the review and analysis .

Results and Conclusion : Autophagy and apoptosis play an important role in ischemia - reperfusion injury of kidney . Through the intervention and regulation of autophagy , the degree of reperfusion injury and the recovery after injury can be affected . It may be a new target for preventing and treating ischemia - reperfusion injury in kidney .
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R699.2

【共引文献】