年龄小于50岁前列腺癌患者的临床分析

发布时间：2018-06-08 02:12

本文选题：前列腺癌 + 前列腺癌根治术　；参考：《浙江大学》2015年硕士论文

【摘要】：目的：前列腺腺癌是老年男性常见的恶性肿瘤,50以下男性前列腺腺癌也在逐年增加。探讨年龄50岁前列腺腺癌患者的临床特征。方法：回顾性分析2008年1月至2014年3月收治的21例前列腺腺癌患者的临床资料。确诊时年龄42～49岁,中位值48岁。tPSA10μg/L17例,4～10μg/L4例。21例均经病理确诊。Gleason评分6分3例,7分6例(3+4分5例,4+3分1例),8分7例,9分5例。临床分期T2N0M0期16例,T3NoMo期1例,T4NxM0期1例,T3-4N1M1期3例。16例(T2N0M0期15例,T3N0Mo期1例)行根治性前列腺切除术,5例行药物去势治疗。结果：行根治性前列腺切除术16例中,随访3-65个月,中位值23个月,14例无生化复发,1例因包膜侵犯术后1个月行辅助性外放疗,tPSA降至0.2μg/L,1例术后18个月出现生化复发,行辅助性外放疗,tPSA降至4.0μg/L。16例术后均尿控良好。行药物去势治疗5例中,2例分别于治疗63、65个月内死亡；1例治疗4个月后,PSA降至2.0μg/L；1例治疗24个月出现去势抵抗,行辅助性外放疗；1例失访。结论：年龄50岁的前列腺腺癌临床分期早,Gleason评分高。对肿瘤局限的患者,应首选根治性前列腺切除术治疗。晚期患者疾病进展较快,预后较差。
[Abstract]:Objective: prostate adenocarcinoma is a common malignant tumor in elderly men. Methods: the clinical data of 21 patients with prostate adenocarcinoma from January 2008 to March 2014 were analyzed retrospectively. At the time of diagnosis, the age was 42 to 49 years old, the median value was 48 years old. TPSA10 渭 g / L 17 cases were 410 渭 g / L 4 cases. 21 cases were confirmed by pathological diagnosis. Gleason score was 6 points in 3 cases, 7 cases in 6 cases and 34 minutes in 5 cases (43 minutes), 8 points in 7 cases and 9 minutes in 5 cases. Clinical stage T2N0M0: T3NoMo: 1 case of T4NxM0, 1 case of T3-4N1M1, 3 cases of T3-4N1M1, 16 cases of T2N0M0, 15 cases of stage T3N0Mo) underwent radical prostatectomy and 5 cases of drug castration. Results: 16 cases underwent radical prostatectomy, followed up for 3-65 months. The median value of 23 months was 23 months and 14 cases had no biochemical recurrence. One case received adjuvant external radiotherapy to 0.2 渭 g 路L ~ (-1) / L of adjuvant external radiotherapy for 1 month after operation, and one case had biochemical recurrence at 18 months after operation, and the postoperative urine control was good in all the cases treated with adjuvant external radiotherapy to 4.0 渭 g / L.16. Of the 5 cases treated with drug castration, 2 cases died within 63 months and 65 months respectively. After 4 months of treatment, PSA decreased to 2.0 渭 g / L in 1 case, and castration resistance occurred in 1 case after 24 months of treatment. Conclusion: the clinical stage of prostatic adenocarcinoma aged 50 years is early and the Gleason score is high. Radical prostatectomy should be the first choice for patients with localized tumors. Patients with advanced stage of disease progress faster, poor prognosis.
【学位授予单位】：浙江大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R737.25

【共引文献】