不同性别原发性IgA肾病患者临床病理特征的对比分析

发布时间：2018-06-11 13:35

本文选题：IgA肾病 + 性别　；参考：《西安交通大学学报(医学版)》2017年02期

【摘要】：目的探讨不同性别原发性IgA肾病患者的临床病理特点。方法对经肾脏活检确诊的192例IgA肾病患者不同性别的临床表现、实验室检查及肾脏病理进行对比分析。结果男性患者发病年龄高于女性,肾活检前病程长于女性,水肿的比例低于女性,差异有统计学意义(P0.05)。肾脏穿刺时,男性平均动脉压、血红蛋白、24h尿蛋白定量高于女性,男性高血压、高尿酸血症、高甘油三酯血症比例高于女性;而男性肾小球滤过率(eGFR)低于女性,差异有统计学意义(P0.05)。临床病理类型的性别分布差异有统计学意义(χ~2=12.666,P0.05),均以U-ab型、MP型为主;24h尿蛋白、CKD分组的性别分布差异有统计学意义(Z=-3.118、Z=-3.246,P0.05)。病理Lee分级、免疫荧光类型无性别分布差异(Z=-1.881,χ~2=-0.187,P0.05);肾小管-间质病变分级(TIL分级)的性别分布差异有统计学意义(Z=-3.0432,P0.05);肾小球硬化评分、肾小管间质评分两指标均为男性高于女性(P0.05)。结论原发性IgA肾病患者临床和病理改变存在一定性别差异,男性患者临床病理改变较女性严重。
[Abstract]:Methods 192 patients with IgA nephropathy diagnosed by renal biopsy were compared with each other in clinical manifestation, laboratory examination and renal pathology. Results the onset age of male patients was higher than that of females, the course of disease before renal biopsy was longer than that of females, and the proportion of edema was lower than that of females, and the difference was statistically significant (P 0.05). During renal puncture, the mean arterial pressure and 24-hour urinary protein quantification of hemoglobin in males were higher than those in females. The proportion of hypertension, hyperuricemia and hypertriglyceridemia in males was higher than that in females, while the glomerular filtration rate (GFR) in males was lower than that in females. The difference was statistically significant (P 0.05). The sex distribution of clinicopathological types was significantly different (蠂 ~ (2 / 2) ~ (12.666) P0.05, and the sex distribution of urinary proteinuria CKD was significantly different in 24 hours urinary protein group with U-ab type (P < 0.05). There was a significant difference in the sex distribution of CKD between two groups (Z ~ (-3.118) ~ (-3.246) ~ (-3.246) (P ~ (0.05). There was no difference in the sex distribution of immunofluorescence type between two groups. There was no significant difference in sex distribution between the two groups. There were significant differences in sex distribution between male and female patients with renal tubulointerstitial lesion grade and tubulointerstitial lesion grade, and the glomerulosclerosis score and tubulointerstitial score were both higher in male than in female. Conclusion the clinical and pathological changes of patients with primary IgA nephropathy are different in sex, and the clinicopathological changes of male patients are more serious than that of women.
【作者单位】：西安交通大学医院;西安交通大学第一附属医院肾病中心;
【基金】：国家自然科学基金资助项目(No.81200528)~~
【分类号】：R692.31

【相似文献】