非那雄胺联合坦索罗辛治疗膀胱过度活动临床疗效分析

发布时间：2018-06-12 20:46

本文选题：膀胱过度活动 + 非那雄胺　；参考：《中国医院药学杂志》2015年11期

【摘要】：目的:探讨非那雄胺联合坦索罗辛治疗膀胱过度活动的临床疗效。方法:选取某院泌尿外科收治诊断为膀胱过度活动症患者90例,随机分为2组,其中对照组45例,予口服琥珀酸索利那新5 mg·d-1等常规治疗,10 d为1个疗程,治疗2个疗程;实验组45例,予以口服非那雄胺1 mg·d-1,以及坦索罗辛0.2 mg·d-1,10 d为1个疗程,治疗2个疗程。治疗结束后,对比治疗前后患者尿流率参数、排尿日记参数、生活质量评估(QOL)、OABSS评分以及患者治疗总有效率。结果:(1)2组患者治疗前后尿流率参数水平比较:治疗后,2组患者最大尿流率、平均尿流率以及尿量均增加,且实验组(13.92±3.79)ml·s-1、(7.83±4.01)ml·s-1、(270.31±81.53)ml显著优于对照组(12.69±5.21)ml·s-1、(6.03±1.55)ml·s-1、(239.18±74.97)ml,差异有统计学意义(P0.05);(2)2组患者排尿日记参数比较:治疗后,2组患者排尿次数、尿急次数、急迫性尿失禁次数以及夜尿次数均有所减少,且实验组(9.16±2.24,4.21±2.01,0.65±0.26,1.02±0.85)显著少于对照组(11.45±3.33,6.72±2.24,1.03±0.26,1.78±0.97),差异有统计学意义(P0.05);(3)2组患者生活质量评估(QOL)比较:治疗后,2组患者生活质量评分均有所上升,且实验组(89分)显著优于对照组(74分),差异有统计学意义(P0.05);(4)2组患者OABSS评分水平比较:治疗后,2组患者OABSS得分均有所下降,且实验组(2分)下降水平显著优于对照组(6分),差异有统计学意义(P0.05);(5)2组患者治疗后总有效率比较:治疗后,实验组(89%)总有效率显著高于对照组(78%),差异有统计学意义(P0.05)。结论:非那雄胺联合坦索罗辛能够明显改善膀胱过度活动症状,对临床具有指导意义,值得临床推广。
[Abstract]:Objective: to investigate the clinical effect of fenasteride combined with tamsoloxine in the treatment of bladder hyperactivity. Methods: ninety patients with bladder hyperactivity were randomly divided into two groups: the control group (n = 45) was treated with oral routine therapy of suolinaxine (5 mg 路d ~ (-1) for 10 days and two courses of treatment. The experimental group (n = 45) was treated with fenasteride (1 mg 路d ~ (-1) and tamsoloxine (0.2 mg 路d ~ (-1) for 10 days. After treatment, the parameters of urinary flow rate, urination diary, quality of life (QOLN) OABSS and the total effective rate of treatment were compared before and after treatment. Results comparison of urine flow rate parameters before and after treatment in two groups: after treatment, the maximum flow rate, mean flow rate and urine volume of the two groups were increased. Moreover, the experimental group (13.92 卤3.79)ml s-1) 7.83 卤4.01)ml s-1n 270.31 卤81.53)ml was significantly better than the control group (12.69 卤5.21)ml s-1n = 6.03 卤1.55)ml s-1n = 239.18 卤74.97ml). The difference was statistically significant (P 0.05). Comparison of the diaries of urination between the two groups: after treatment, the number of urination, the number of urgent urinary incontinence and the times of nocturnal urination were decreased in both groups. The QOLs in the experimental group were significantly lower than those in the control group (11.45 卤3.33 卤6.72 卤0.261.73 卤0.261.78 卤0.97). The OABSS score of the experimental group was significantly higher than that of the control group (P 0.05) and the OABSS score of the two groups was significantly lower than that of the control group (P 0.05). The total effective rate of the experimental group (2 points) was significantly higher than that of the control group (6 points), and the difference was statistically significant (P 0.05). The total effective rate of the experimental group was significantly higher than that of the control group (P 0.05). Conclusion: finasteride combined with tamoxoroxine can significantly improve the symptoms of bladder hyperactivity, and is worthy of clinical promotion.
【作者单位】：湖北民族学院附属民大医院;
【分类号】：R694

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