肾损伤分子-1对急性肾损伤患者早期诊断的作用及临床意义

发布时间：2018-06-16 04:28

本文选题：肾损伤分子- + 急性肾损伤　；参考：《中国老年学杂志》2017年16期

【摘要】：目的探讨肾损伤分子(Kim)-1对急性肾损伤患者早期诊断的作用及临床意义。方法 62例急性肾损伤患者根据病情程度分为轻度组与中重度组各31例,另选取同期31例体检健康者为对照组。以酶联免疫吸附(ELISA)法对各组尿液Kim-1进行检测,以比色法对各组尿液NAG酶进行检测,以黄嘌呤氧化酶法对各组血清超氧化物歧化酶(SOD)进行检测,以六代巴比妥酸比色法对各组血清丙二醛(MDA)进行检测。对比各组尿Kim-1、尿NAG、血清SOD及MDA水平,分析尿Kim-1与尿NAG、血清SOD及MDA的相关性。结果轻度组与中重度组尿Kim-1、尿NAG酶、血清SOD及MDA水平均显著高于对照组(P0.05),轻度组与中重度组差异有统计学意义(P0.05);尿Kim-1与尿NAG酶、血清SOD、血清MDA呈正相关(r=0.723,0.503,0.544,均P0.05)。结论尿Kim-1是急性肾损伤发病时较早出现的一项指标,与尿NAG酶相比具有较高敏感性,可将其作为早期诊断急性肾损伤的内源性标志物。
[Abstract]:Objective to investigate the effect and clinical significance of renal injury molecule kimurone-1 in early diagnosis of acute renal injury. Methods Sixty-two patients with acute renal injury were divided into mild group (31 cases) and moderate to severe group (31 cases). Urine Kim-1 was detected by Elisa, nag enzyme in urine was detected by colorimetry, serum superoxide dismutase (SOD) was detected by xanthine oxidase method. Serum malondialdehyde (MDA) was determined by six generation barbituric acid colorimetry. The levels of urinary Kim-1, urinary nag, serum SOD and MDA were compared, and the correlation between urinary Kim-1 and urinary NAG, serum SOD and MDA was analyzed. Results the levels of urine Kim-1, nag enzyme, serum SOD and MDA in mild and moderate severe group were significantly higher than those in control group (P 0.05), and there was significant difference between mild group and moderate and severe group (P 0.05), and there was a positive correlation between urine Kim-1 and urinary nag enzyme, serum SOD, serum MDA (P 0.05). Conclusion urinary Kim-1 is an early marker of acute renal injury. Compared with urinary nag enzyme, it has a high sensitivity and can be used as an endogenous marker for early diagnosis of acute renal injury.
【作者单位】：重庆市中医院;
【分类号】：R692.5

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