西宁地区高通量透析治疗对患者血清钙、磷、iPTH的影响

发布时间：2018-06-19 14:37

本文选题：肾性骨病 + 普通透析　；参考：《青海大学》2015年硕士论文

【摘要】：目的:1、旨在通过监测高通量透析治疗(HFHD)后血清钙、磷、i PTH的水平变化了解高通量透析治疗对中、大分子毒素的清除效果,从而进一步肯定高通量透析治疗的临床疗效,提高维持性血液透析(MHD)的患者对高通量透析治疗的认识。2、通过不同透析方式治疗后对肾性骨病相关指标的检测,对普通透析治疗(CHD)及高通量透析治疗的疗效进行对比,为透析患者拟定治疗方案提供进一步的帮助及临床指导。方法:选择2013年8月-2014年8月在青海大学附属医院血液净化中心进行维持性血液透析治疗的患者71例,其中普通透析治疗超过6个月的患者39例,普通透析治疗超过6个月后改为高通量透析治疗6个月的患者32例,记录患者基本资料。监测普通透析3个月、6个月及高通量透析3个月、6个月后钙、磷、i PTH等相关指标的水平,进行回顾性分析。应用SPSS19.0软件进行统计分析。结果:1、普通透析治疗6个月后较治疗前血磷水平无明显变化,血i PTH水平有所下降。2、高通量透析治疗后比普通透析治疗后血磷、i PTH水平降低,血钙水平升高。3、普通透析治疗6个月改为高通量透析治疗6个月后血磷、i PTH水平明显降低,血钙水平无明显变化。结论:1、普通透析治疗对患者血磷清除作用不明显,对血i PTH有一定的清除作用。2、高通量透析治疗对患者血清磷、甲状旁腺激素PTH的清除作用明显。3、高通量透析治疗对中、大分子毒素的清除作用较普通透析治疗显著。
[Abstract]:Objective: to investigate the effect of high flux dialysis on the clearance of macromolecular toxins by monitoring the changes of serum calcium, phosphorus and PTH levels after high flux dialysis therapy (HFHD), so as to confirm the clinical efficacy of high throughput dialysis therapy. To improve the understanding of high-throughput dialysis treatment in patients with maintenance hemodialysis (MHD), to detect the relative indexes of renal osteopathy after different dialysis methods, and to compare the curative effects of general dialysis treatment with high-throughput dialysis treatment. To provide further help and clinical guidance for dialysis patients to develop treatment plan. Methods: from August 2013 to August 2014, 71 patients were treated with maintenance hemodialysis in the blood purification center of the affiliated Hospital of Qinghai University, 39 of whom were treated with general dialysis for more than 6 months. After 6 months of general dialysis treatment, 32 patients were treated with high flux dialysis for 6 months, and the basic data of the patients were recorded. The levels of calcium, phosphorus and PTH were monitored after 3 months, 6 months and 3 months of high flux dialysis. SPSS 19.0 software was used for statistical analysis. Results there was no significant change in blood phosphorus level after 6 months of conventional dialysis treatment, and the level of plasma I PTH decreased by 0.2, and after high-throughput dialysis treatment, the blood phosphorus level decreased after 6 months of conventional dialysis treatment. The level of serum calcium was increased by .3.After 6 months of general dialysis treatment, the level of PTH decreased significantly, but the level of serum calcium did not change significantly after 6 months of high-throughput dialysis treatment. Conclusion: the effect of routine dialysis therapy on the clearance of blood phosphorus is not obvious, but it has a certain scavenging effect on blood I PTH. The clearance of serum phosphorus and parathyroid hormone PTH by high flux dialysis therapy is significant. The effect of high flux dialysis therapy on the clearance of serum phosphorus and parathyroid hormone PTH is significant. The scavenging effect of macromolecular toxin was more significant than that of general dialysis treatment.
【学位授予单位】：青海大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R692.5

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