影响多西他赛联合泼尼松治疗转移性去势抵抗性前列腺癌疗效的因素分析

发布时间：2018-06-25 21:33

  本文选题：前列腺癌 + 去势抵抗性　； 参考：《北京大学学报(医学版)》2015年04期

【摘要】：目的:探讨转移性去势抵抗性前列腺癌(metastatic castration resistant prostate cancer,m CRPC)患者接受多西他赛+泼尼松治疗有效性的影响因素。方法:回顾性分析2010年2月至2015年3月在北京大学第一医院转移性去势抵抗性前列腺癌患者接受多西他赛联合泼尼松治疗有效性的影响因素。研究纳入的多西他赛联合泼尼松治疗的m CRPC患者的临床资料,对相关的临床因素进行单因素分析。结果:共60例患者接受治疗,对其中33例临床资料完整的患者进行分析。化疗有效定义为化疗4个周期后前列腺特异性抗原(prostate specific antigen,PSA)较基线下降≥50%,且影像学改变按照实体肿瘤疗效评价标准(response evaluation criteria in solid tumors,RECIST)无进展。其化疗时中位PSA为153.4μg/L(6.6~9 952.0μg/L),共20例(60.6%)为治疗有效,单因素分析后发现Gleason评分较低者化疗有效性较差(P=0.034);化疗时存在淋巴结转移者有效率较高(P=0.032);内脏转移者共15例,其中12例(80%)患者治疗有效(P=0.041);化疗时出现贫血的患者(HGB≤120 g/L)共10例,化疗有效者3例(30%,P=0.024)。结论:对于m CRPC患者,初发时Gleason评分≤7、诊断时合并淋巴结转移、内脏转移以及化疗时存在贫血是化疗能否有效的预测因素。
[Abstract]:Objective: to investigate the factors influencing the efficacy of docetaxel prednisone in metastatic ovariectomized prostate cancer (metastatic castration resistant prostate cancer-CRPC). Methods: the factors influencing the efficacy of docetaxel combined with prednisone in metastatic ovariectomized prostate cancer patients in Peking University first Hospital from February 2010 to March 2015 were analyzed retrospectively. The clinical data of m CRPC patients treated with docetaxel combined with prednisone were analyzed by univariate analysis. Results: a total of 60 patients were treated and 33 patients with complete clinical data were analyzed. The effective definition of chemotherapy is that the prostate specific antigen (prostate specific antigen-PSA) decreases more than 50% compared with baseline after 4 cycles of chemotherapy, and no progress has been made in imaging changes according to the criteria for evaluating the efficacy of solid tumors, (response evaluation criteria in solid tumors / RECIST. At the time of chemotherapy, the median PSA was 153.4 渭 g / L (6.6 渭 g / L, 9 952.0 渭 g / L), and 20 cases (60.6%) were effective. Univariate analysis showed that the Gleason score was lower than that of the lower Gleason score (P0. 034), the effective rate of lymph node metastasis was higher (P0. 032), and the visceral metastasis was 15 cases. Among them, 12 cases (80%) were effective (P0. 041), 10 cases (HGB 鈮，

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