黄体酮注射液联合硝苯地平片治疗输尿管上段结石的临床研究

发布时间：2018-06-26 11:04

本文选题：黄体酮 + 硝苯地平　；参考：《中国临床药理学杂志》2017年07期

【摘要】：目的观察黄体酮注射液联合硝苯地平片治疗输尿管上段结石的临床疗效。方法将94例输尿管上段结石患者随机分为对照组47例与试验组47例。对照组给予盐酸消旋山莨菪碱注射液5~10 mg,qd,肌内注射;试验组在对照组的基础上给予黄体酮注射液20 mg,bid,肌内注射,硝苯地平片10 mg,tid,舌下含服。2组均治疗14 d。比较2组患者的临床疗效、治疗前后血清C-反应蛋白(CRP)、白细胞介素-6(IL-6)水平及药物不良反应发生情况。结果治疗后,试验组和对照组的总有效率分别为95.74%(45/47例)和82.98%(39/47例),差异有统计学意义(P0.05)。治疗后,试验组和对照组的CPR分别为(2.17±0.25),(3.45±0.42)mg·L(-1);IL-6分别为(4.72±0.51),(8.34±0.89)ng·L~(-1),差异均有统计学意义(P0.05)。试验组主要药物不良反应为口干、视物模糊、皮疹;对照组主要药物不良反应为口干、心跳加速、排尿困难以及皮疹,试验组和对照组的药物不良反应发生率分别为6.38%和10.64%,差异有统计学意义(P0.05)。结论黄体酮联合硝苯地平治疗输尿管上段结石的临床疗效显著,安全性高。
[Abstract]:Objective to observe the clinical effect of progesterone injection combined with nifedipine tablets in the treatment of upper ureteral calculi. Methods 94 patients with upper ureteral calculi were randomly divided into control group (n = 47) and experimental group (n = 47). The control group was given 5-10 mg of anisodamine hydrochloride injection intramuscularly, and the experimental group was given 20 mg of progesterone injection, intramuscular injection, nifedipine tablet 10 mg / L tid, and the sublingual group was treated for 14 days on the basis of intramuscular injection of progesterone injection (20 mg / kg). The clinical efficacy, serum C-reactive protein (CRP), interleukin-6 (IL-6) levels and adverse drug reactions were compared between the two groups. Results after treatment, the total effective rates of the experimental group and the control group were 95.74% (45 / 47 cases) and 82.98% (39 / 47 cases), respectively. The difference was statistically significant (P0.05). After treatment, the CPR of the trial group and the control group were (2.17 卤0.25), (3.45 卤0.42) mg / L (-1) and (4.72 卤0.51), () 卤(8.34 卤0.89) ng / L ~ (-1), respectively (P0.05). The main adverse drug reactions in the test group were dry mouth, blurred vision and rash. In the control group, the main adverse drug reactions were dry mouth, rapid heartbeat, dysuria and rash. The incidence of adverse drug reactions in the test group and the control group was 6.38% and 10.64%, respectively. The difference was statistically significant (P0.05). Conclusion progesterone combined with nifedipine is effective and safe in the treatment of upper ureteral calculi.
【作者单位】：泉州市第一医院碎石中心;
【基金】：泉州市卫生科研基金资助项目[泉卫函(2014)267号]
【分类号】：R693.4

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