尿可溶性Fas和血管内皮生长因子在膀胱癌中表达的意义及相关性研究

发布时间：2018-06-28 04:28

本文选题：可溶性Fas + 膀胱癌　；参考：《中国现代医学杂志》2015年05期

【摘要】：目的探讨尿可溶性Fas(s Fas)和血管内皮生长因子(VEGF)在膀胱癌患者中表达的意义及相关性。方法采用病例对照研究方法,随机抽取膀胱癌患者和对照者各82例,采用酶联免疫分析法(ELISA)测定标本尿s Fas水平,采用免疫组织化学SP法检测膀胱癌标本中VEGF的表达。结果尿s Fas在膀胱癌病例组为(168.0±84.6)ng/ml,对照组为(56.2±37.0)ng/ml,差异有统计学意义(P0.01)。尿s Fas随着病理分期的增加而增加(P0.01)。VEGF在膀胱癌病例组的表达阳性率为74.4%(61/82),与膀胱癌病理分期、组织学分级呈正相关(P0.01)。与VEGF阴性表达组比较,VEGF阳性表达组的尿s Fas浓度增高,并且尿s Fas浓度随着VEGF表达的增加而增高,差异有统计学意义(P0.01)。结论 s Fas和VEGF可能在膀胱癌的发生、发展中发挥着协同作用,检测尿s Fas和VEGF有利于判断膀胱癌的进展和预后。
[Abstract]:Objective to investigate the significance and correlation of urinary soluble FAS (sFAS) and vascular endothelial growth factor (VEGF) expression in bladder cancer. Methods 82 cases of bladder cancer and 82 cases of control were randomly selected by case-control study. The levels of urinary SFAS were measured by enzyme linked immunosorbent assay (Elisa) and the expression of VEGF in bladder cancer samples was detected by immunohistochemical SP method. Results urinary SFAS levels were (168.0 卤84.6) ng / ml in bladder cancer group and (56.2 卤37.0) ng / ml in control group (P0.01). The positive rate of urinary SFAS expression in bladder cancer patients was 74.4% (61 / 82), which was positively correlated with the pathological stage and histological grade of bladder cancer (P0.01). Compared with the negative expression group, the urinary SFAS concentration in the VEGF positive group was higher than that in the VEGF negative expression group, and the urinary SFAS concentration was increased with the increase of VEGF expression, the difference was statistically significant (P0.01). Conclusion SFAS and VEGF may play a synergistic role in the occurrence and development of bladder cancer. Detection of SFAS and VEGF in urine is helpful to judge the progression and prognosis of bladder cancer.
【作者单位】：河北省石家庄市第一医院男科;河北省石家庄市第一医院泌尿外科;承德医学院附属医院泌尿外科;
【分类号】：R737.14

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