肾结石合并尿路感染的菌谱及耐药性分析

发布时间：2018-06-28 05:19

  本文选题：肾结石 + 尿路感染　； 参考：《现代泌尿外科杂志》2017年10期

【摘要】：目的探讨广州医科大学附属第一医院泌尿外科肾结石合并尿路感染的感染率、病原菌分布及耐药性,为临床合理用药提供依据。方法收集广州医科大学附属第一医院泌尿外科2009年1月至2016年12月肾结石合患者中段尿培养资料,统计并分析菌谱和耐药性的变化。结果从14 063份肾结石患者中段尿标本中分离致病菌3 280株,阳性率为23.3%。肾结石合并尿路感染主要致病菌为大肠埃希菌(47.13%),肺炎克雷伯菌(8.35%)、粪肠球菌(8.14%)、奇异变形杆菌(7.10%)和铜绿假单胞菌(4.97%)。大肠埃希菌、肺炎克雷伯菌、铜绿假单胞菌和奇异变形杆菌对阿米卡星、哌拉西林/他唑巴坦、亚胺培南耐药率≤10%,鲍曼不动杆菌对头孢吡肟、亚胺培南耐药率≥20.00%。粪肠球菌、屎肠球菌和凝固酶阴性葡萄球菌对万古霉素和替考拉宁的敏感率为100%。结论大肠埃希菌是肾结石患者合并尿路感染的主要致病菌,对青霉素类、喹诺酮类、第3代头孢菌素、磺胺类抗菌药物耐药率较高;对阿米卡星、β-内酰胺酶抑制剂复合制剂、亚胺培南等药物敏感。
[Abstract]:Objective to investigate the infection rate, distribution and drug resistance of renal calculi complicated with urinary tract infection in the first affiliated Hospital of Guangzhou Medical University. Methods the data of urinary culture from January 2009 to December 2016 in urology department of the first affiliated Hospital of Guangzhou Medical University were collected and the changes of bacterial spectrum and drug resistance were analyzed. Results 3 280 strains of pathogenic bacteria were isolated from 14 063 urine samples from patients with renal calculi, the positive rate was 23. 3%. The main pathogens of renal calculi with urinary tract infection were Escherichia coli (47.13%), Klebsiella pneumoniae (8.35%), Enterococcus faecalis (8.14%), Proteus mirabilis (7.10%) and Pseudomonas aeruginosa (4.97%). Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Proteus mirabilis were resistant to amikacin, piperacillin / tazobactam, imipenem 鈮，

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