蛋白P27、Survivin和骨桥蛋白在前列腺癌组织中的表达和意义

发布时间：2018-06-29 10:25

本文选题：前列腺癌 + 蛋白P　；参考：《中国老年学杂志》2016年04期

【摘要】：目的探讨蛋白P27、Survivin和骨桥蛋白(OPN)在前列腺癌(PCa)组织中的表达及意义。方法采用免疫组织化技术对PCa和癌旁组织标本中的蛋白P27、Survivin和OPN进行分析。结果 80例PCa组织中,蛋白P27、Survivin、OPN阳性表达率与癌旁组织,差异显著(P=0.015);P27表达与PCa病理分期(P=0.026)、临床分期(P=0.037)和有无淋巴结转移(P=0.033)有关,;Survivin表达与PCa病理分期(P=0.041)、临床分期(P=0.039)和有无淋巴结转移(P=0.031)有关,OPN表达与PCa病理分期(P=0.023)、临床分期(P=0.034)和有无淋巴结转移(P=0.027)有关;P27和Survivin,P27和OPN在PCa组织中表达呈负相关(P0.001)。结论临床中联合检测蛋白P27、Survivin和OPN为前列腺癌的防治和治疗提供一种治疗策略。
[Abstract]:Objective to investigate the expression and significance of survivin and osteopontin (OPN) in prostate cancer (PCA). Methods Immunohistochemistry was used to analyze the protein P27 survivin and OPN in PCA and paracancerous tissues. Results in 80 cases of PCA, the positive expression rate of protein P27, survivin and OPN was found to be higher than that in adjacent tissues. There was significant difference between the expression of P27 and pathological stage of PCA (P0. 026), clinical stage (P0. 037) and lymph node metastasis (P0. 033). The expression of survivin was related to the pathological stage of PCA (P0. 041), clinical stage (P0. 039) and lymph node metastasis (P0. 031) were related to the expression of OPN and the pathological stage of PCA (P0. 023), clinical stage was related to the expression of survivin and the pathological stage of PCA (P0. 023). The expression of P27 and survivin P27 and OPN were negatively correlated with lymph node metastasis (P0. 027) in PCA tissues (P0. 001). Conclusion the combined detection of protein P27 survivin and OPN provides a therapeutic strategy for the prevention and treatment of prostate cancer.
【作者单位】：苏州大学附属第一医院;
【基金】：内蒙古自治区自然科学基金项目(No.2015M30877)
【分类号】：R737.25

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