CatSper蛋白对精子超活化运动和男性不育影响的研究进展

发布时间：2018-07-01 18:57

本文选题：Ca~(+) + CatSper通道　；参考：《中华男科学杂志》2017年08期

【摘要】：CtaSper通道是目前公认的哺乳动物精子细胞膜上最重要的Ca~(2+)通道,对精子运动、精子超活化和受精功能起着关键作用。Cat Sper蛋白只表达于精子尾部主段,由CatSper1-4和5个辅助单元β、γ、δ、ε和ζ构成。CatSper蛋白是Ca~(2+)功能结构域的主体,在时空上均有序调控精子尾部蛋白酪氨酸磷酸化(P-Tyr),维持了精子超活化运动。CatSper~(-/-)小鼠超活化表现为早发式、爆发式、散发式,能量很快耗尽,超活化提前终止。胞内p H值、膜电位、类固醇激素、多种蛋白质、环腺苷酸类似物等通过调控CatSper通道参与精子超活化、精子游动至受精部位和穿透卵子外膜。近年来,许多研究证实CatSper蛋白功能缺陷会严重影响精子功能,9个CatSper亚基的中任何一个丢失最终导致男性生育功能障碍。本文结合目前最新研究进展,从CatSper蛋白表达、定位、结构、调控等多角度就CatSper对精子超活化和男性不育的影响进行综述。
[Abstract]:CtaSper channel is the most important Ca ~ (2) channel in mammalian sperm cell membrane. It plays a key role in sperm motility, sperm superactivation and fertilization function. Cat Sper protein is expressed only in the main part of sperm tail. CatSper protein consists of CatSper1-4 and five auxiliary units 尾, 纬, 未, 蔚 and 味. CatSper protein is the main body of Ca2 functional domain. It regulates the tyrosine phosphorylation (P-Tyr) of sperm tail protein in time and space, and maintains the superactivation of spermatozoa. Detonation, exuberance, energy depletion and early termination of superactivation. Intracellular pH, membrane potential, steroid hormones, various proteins and cyclic adenylate analogues are involved in the superactivation of spermatozoa by regulating the CatSper channel, the sperm swim to the fertilized site and penetrate the outer membrane of the egg. In recent years, many studies have confirmed that the dysfunction of CatSper protein can seriously affect sperm function, and any of the 9 CatSper subunits may lead to male reproductive dysfunction. In this paper, the effects of CatSper on sperm hyperactivation and male infertility were reviewed from the perspectives of CatSper protein expression, localization, structure and regulation.
【作者单位】：天津医科大学第二医院泌尿外科;天津医科大学总医院生殖医学中心;
【基金】：天津市卫生和计划生育委员会攻关项目(14KG138)~~
【分类号】：R698.2

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