IgA肾病患者病理与临床指标的相关性分析

发布时间：2018-07-02 08:00

本文选题：IgA肾病 + 肾活检　；参考：《上海交通大学学报(医学版)》2017年10期

【摘要】：目的·分析肾活检病理确诊IgA肾病患者的病理与临床资料,研究IgA肾病患者的临床指标与患者肾脏病理损伤程度的相关性。方法·回顾性分析同济大学附属东方医院肾内科2012—2016年期间肾活检病理确诊为IgA肾病的73例患者的病理资料,比较不同病理分级、分型和损伤程度的患者血压、血尿酸、血肌酐、血尿素氮、24h尿蛋白定量、估算的肾小球滤过率(eGFR)、三酰甘油、总胆固醇、补体C3等临床指标,并进行相关性分析。结果·73例IgA肾病患者平均年龄为(37.07±12.58)岁,男女比为1.21∶1。不同Hass分级和不同牛津病理分型的患者,其血尿酸、血肌酐、血尿素氮及eGFR间差异有统计学意义(均P0.05)。血清补体C3水平及肾组织局部免疫荧光沉积强度与病理分级间存在相关性,即血清补体C3水平越低,免疫荧光沉积越强,其病理分级越严重,肾功能损害也越严重。结论·IgA肾病患者的临床指标可用于预测患者肾脏病理损伤程度,血尿酸、血肌酐、血尿素氮、eGFR及血清补体C3水平可作为临床早期判断患者病理损伤程度和病程进展的指标。
[Abstract]:Objective to analyze the pathological and clinical data of IgA nephropathy diagnosed by renal biopsy, and to study the correlation between the clinical indexes of IgA nephropathy and the degree of renal pathological injury. Methods the pathological data of 73 patients with IgA nephropathy confirmed by renal biopsy from 2012 to 2016 in the Department of Nephrology, Oriental Hospital affiliated to Tongji University were analyzed retrospectively. The blood pressure and serum uric acid of the patients with different pathological grades, types and degree of injury were compared. Serum creatinine, 24 hours urine protein of blood urea nitrogen, estimated glomerular filtration rate (eGFR), triacylglycerol, total cholesterol, complement C3, and so on, were analyzed. Results the average age of 73 patients with IgA nephropathy was (37.07 卤12.58) years, the ratio of male to female was 1.21: 1. There were significant differences in serum uric acid, serum creatinine, blood urea nitrogen and eGFR among patients with different Hass grade and different Oxford pathological classification (P0.05). The level of serum complement C3 and the intensity of local immunofluorescence deposition in renal tissue were correlated with pathological grade. The lower the level of serum complement C3, the stronger the deposition of immunofluorescence, the more serious the pathological grade and the more serious the damage of renal function. Conclusion the clinical indexes of IgA nephropathy can be used to predict the degree of renal pathological injury, serum uric acid, serum creatinine, blood urea nitrogen eGFR and serum complement C3 levels.
【作者单位】：同济大学附属东方医院肾内科;
【基金】：国家自然科学基金(81200492,81470991,81670690,81670623,81470920,81270778) 上海市浦江人才计划(13PJ1406900) 上海市浦东新区卫生系统重点学科建设项目(PWZx2017)~~
【分类号】：R692.31

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