肾性贫血、超敏C反应蛋白对慢性肾脏病患者心血管并发症影响的情况分析

发布时间：2018-07-03 05:24

  本文选题：慢性肾脏病 + 肾性贫血　； 参考：《广西医科大学》2014年硕士论文

【摘要】：目的探讨慢性肾脏病患者心血管并发症情况,及贫血、超敏C反应蛋白对慢性肾脏病心血管并发症的影响。 方法收集2010年3月至2013年7月期间在南宁市第一人民医院肾内科住院的942例慢性肾脏病肾性贫血患者的临床及实验室资料。 结果1、942例慢性肾脏病肾性贫血患者中,CKD1期患者16例(1.70%)、CKD2期患者42例(4.46%)、CKD3期患者174例(18.47%)、CKD4期患者153例(16.42%)、CKD5期患者557例(59.13%)；CKD1-5期患者血红蛋白均值分别为100.13±11.45g/L、99.21±13.34g/L、98.88±11.65g/L91.53±13.90g/L、78.94±18.02g/L。2、慢性肾脏病患者冠状动脉疾病(CAD)、左心室肥厚(LVH)、充血性心力衰竭(CHF)、脑卒中(CVA)、大血管动脉粥样硬化性疾病(LAD)的患病率分别为31.25%、54.76%、58.05%、60.78%、65.88%,其中CKD1-5期各组间CAD、LVH、CHF的患病率增加(P0.01),CVA、LAD的患病率无统计学差异。3、将贫血分为轻度、中度、重度3组,随着贫血的加重,CAD、LVH患病率增加(P0.01),而CHF、CVA、LAD的患病率无统计学差异。4、按hs-CRP水平分为低危组(hs-CRP1.0mg/L)、中危组(1.0mg/L≤hs-CRP≤3.0mg/L)、高危组(hs-CRP3.0mg/L),3组间CAD、LVH、CHF、CVA、LAD的患病率均有所增加,有统计学差异(P0.05)。 结论：1、随着肾功能的下降,贫血程度逐渐加重。2、肾功能下降增加CAD、LVH、CHF的患病率,对CVA、LAD影响无统计学差异。3、慢性肾脏病患者随着贫血的加重,CAD、LVH的患病率增加。4、慢性肾脏病患者随着hs-CRP升高,心血管并发症(CAD、LVH、CHF、CVA、LAD)患病率增加。
[Abstract]:Objective to investigate the cardiovascular complications in patients with chronic kidney disease and the effects of anemia and hypersensitive C reactive protein on cardiovascular complications in patients with chronic kidney disease. Methods the clinical and laboratory data of 942 patients with renal anemia of chronic kidney disease were collected from March 2010 to July 2013 in Nanning first people's Hospital. Results among 1942 patients with renal anemia of chronic kidney disease, 16 (1.70%) were in CKD1 stage, 42 (4.46%) in CKD2 stage, 174 (18.47%) in CKD3 stage, 153 (16.42%) in CKD4 stage and 557 (59.13%) in CKD5 stage. The mean hemoglobin values of CKD1-5 patients were 100.13 卤11.45g / L 99.21 卤13.34g / L 91.53 卤13.90g / L 91.53 卤13.90g / L 78.94 卤18.02g / L, respectively. The prevalence of CKD1-5 was 60.7888 in patients with chronic renal disease, left ventricular hypertrophy (LVH), congestive heart failure (CHF), stroke (CVA), and major atherosclerotic disease (lad). There was no significant difference in the prevalence of CADV LVHV CHF among the three groups (P0.01), and anemia was classified as mild. The prevalence of LVH increased with the exacerbation of anemia (P0.01), but there was no significant difference in the prevalence of CHFV-CVALAD. According to the level of hs-CRP, it was divided into low risk group (hs-CRP 1.0 mg / L), moderate risk group (1.0 mg / L 鈮，

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