超声剪切波技术在慢性肾脏疾病诊断中的应用研究

发布时间：2018-07-10 06:31

  本文选题：超声 + 常规超声　； 参考：《吉林大学》2014年硕士论文

【摘要】：目的：应用超声剪切波技术检测63例不同程度慢性肾脏疾病患者的肾脏皮质，将检测结果与患者临床表现、疾病分期、肾功能检验等资料进行对照分析，进一步探讨超声剪切波技术在慢性肾脏疾病的诊断及分期上的应用价值，为超声剪切波技术在肾脏疾病中的应用研究积累资料。 方法：以2012年10月～2014年2月期间在我院肾病内科就诊及住院治疗的63例患者及30例健康成人作为研究对象。慢性肾脏疾病诊断标准是：不论何种原因导致的肾脏损害或者肾功能下降即肾小球率过滤（GFR）每1.73平方米＜60ml/min，并且持续三个月以上者。对所有研究对象的左肾进行二维超声、彩色多普勒超声和超声剪切波检查。将研究对象的超声检查资料与实验室检查资料进行比较分析[8]。 结果：63例慢性肾脏疾病（CKD）患者分为CKD1期（16例）、CKD2期（13例）、CKD3期（11例）、CKD4期（10例）、CKD5期（13例）。超声剪切波技术检测VTQ值：CKD1期患者测值2.46±0.34；CKD2期患者测值2.30±0.48；CKD3期患者测值2.06±0.27；CKD4期患者测值1.86±0.52；CKD5期患者测值1.08±0.36；正常对照组测值3.04±0.23。 正常组VTQ值均＞CKD各期VTQ值，P＜0.001，差异有统计学意义；CKD1期VTQ值＞CKD3、CKD4、CKD5期VTQ值，P＜0.05，差异有统计学意义；。CKD5期VTQ值均＜CKD1、CKD2、CKD3、CKD4期VTQ值，P＜0.05，差异有统计学意义；CKD1期与CKD2期比较、CKD2期与CKD3期比较、CKD3期与CKD4期比较，VTQ值差异P＞0.05，无统计学意义。 结论：1.慢性肾脏疾病组超声VTQ测值小于正常组。超声VTQ技术对慢性肾脏疾病的诊断有临床意义。将VTQ值≤2.67作为诊断慢性肾脏疾病的分界点，可为临床诊断提供参考。2.超声VTQ测值对诊断早期慢性肾脏疾病及对慢性肾脏疾病的分期诊断有一定的临床应用价值。3慢性肾脏疾病组肾脏VTQ测值与患者血清肌酐测值及尿素氮测值呈负性相关性，，根据VTQ测值判断慢性肾脏疾病患者的肾功能有一定可行性。
[Abstract]:Objective: to detect the renal cortex of 63 patients with different degrees of chronic renal disease by using ultrasonic shear wave technique, and to compare the results with the clinical manifestations, disease stages, renal function test and so on. To further explore the application value of ultrasonic shear wave technique in the diagnosis and staging of chronic renal disease, and to accumulate data for the application of ultrasonic shear wave technique in kidney disease. Methods: from October 2012 to February 2014, 63 patients and 30 healthy adults were enrolled in the study. The diagnostic criteria for chronic renal disease were as follows: glomerular filtration (GFR) was less than 60 ml / min per 1.73 m2 and lasted for more than three months, regardless of the cause of renal damage or decline in renal function. The left kidney of all subjects were examined by two-dimensional ultrasound, color Doppler ultrasound and ultrasonic shear wave. The ultrasonic data of the subjects were compared with the laboratory data [8]. Results Sixty-three patients with chronic renal disease (CKD) were divided into CKD1 (16 cases), CKD2 (13 cases), CKD3 (11 cases), CKD4 (10 cases) and CKD5 (13 cases). The VTQ value was 2.46 卤0.34 + CKD2 by ultrasonic shear wave technique, and the value was 2.06 卤0.27CKD4 stage 1.86 卤0.52 CKD5 stage and 3.04 卤0.23 in normal control group. The VTQ value of normal group was higher than that of CKD in each stage (P < 0.001), and the difference was statistically significant (P < 0.05). The VTQ value of CKD1 stage was higher than that of CKD4CKD5 stage (P < 0.05), and the VTQ value of CKD5 phase was significantly lower than that of CKD1CKD2CKD3CKD3 CKD4 phase (P < 0.05). There was no significant difference in VTQ between CKD3 and CKD4 compared with CKD1 and CKD2 (P > 0.05). Conclusion 1. The value of VTQ in chronic renal disease group was lower than that in normal group. Ultrasonic VTQ technique has clinical significance in the diagnosis of chronic renal disease. Taking VTQ 鈮

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