增生硬化性IgA肾病（IgAN）进展至终末期肾病（ESRD）的高危因素分析

发布时间：2018-07-10 16:18

本文选题：增生硬化性IgA肾病 + 终末期肾病　；参考：《浙江大学》2015年硕士论文

【摘要】：研究目的：旨在分析增生硬化性IgA肾病(IgAN)进展至终末期肾病(ESRD)的高危因素。研究方法：回顾性分析2004年到2012年于我院行肾脏穿刺活检,病理表现为增生硬化性IgA肾病的71例的临床资料及病例资料。研究结果：尿蛋白(HR1.280,95%CI1.013-1.616,P=0.039),eGFR(HR0.956,95%CI0.932-0.982,P=0.001),血红蛋白(HR0.977,95%CI0.959-0.996,P=0.015)是最终发生ESRD的独立危险因素。研究结论：我们的研究表明,对于增生硬化性IgAN,尿蛋白,eGFR,血红蛋白是最终进展至ESRD的独立危险因素,临床上因行积极干预治疗,延缓ESRD的发生。RAS阻断剂治疗对于延缓ESRD的发生十分有帮助。
[Abstract]:Objective: to analyze the risk factors for progression of proliferative sclerosing IgA nephropathy (IgAN) to end stage nephropathy (ESRD). Methods: the clinical data and data of 71 cases with proliferative sclerosing IgA nephropathy were analyzed retrospectively from 2004 to 2012. The results showed that urine protein (HR1.280 ~ 95CI1.013-1.616P0.039) eGFR (HR0.956) and hemoglobin (HR0.977C95CI0.959-0.996P0.015) were independent risk factors for ESRD. Conclusion: our study shows that for proliferative sclerosing IgA, urine protein eGFR, hemoglobin is an independent risk factor for the final progression to ESRD. Delaying the occurrence of ESRD. Ras blocker therapy is very helpful to delay the occurrence of ESRD.
【学位授予单位】：浙江大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R692

【参考文献】