2013-2015年马鞍山地区泌尿生殖道感染支原体耐药趋势分析

发布时间：2018-07-16 14:58

【摘要】：目的了解马鞍山地区泌尿生殖道非淋球菌感染男女患者的支原体耐药差异及变化趋势,为临床合理使用抗生素提供指导。方法采用解脲支原体(UU)和人型支原体(MH)培养鉴定药敏试剂盒,对2013-2015年我院皮肤科、泌尿科及妇产科的2 357例送检标本进行培养和药敏试验,用SPSS 22.0软件进行统计学分析。结果 2 357例送检标本中,检出支原体1 040例,检出率为44.12%。女性患者检出率(837例,56.17%)明显高于男性患者检出率(203例,23.41%)。美满霉素及强力霉素敏感率最高(95%),其次为克拉霉素(85%),对喹诺酮类抗生素的敏感率较低,其中氧氟沙星及左氧氟沙星敏感率低于20%。男性患者对交沙霉素、克拉霉素、罗红霉素、斯帕沙星、左氧氟沙星和阿奇霉素敏感率明显高于女性患者(P0.05)。男性患者支原体对交沙霉素、克拉霉素、罗红霉素和阿奇霉素的敏感率呈逐年上升趋势(P0.05)。女性患者支原体对交沙霉素、罗红霉素和阿奇霉素敏感率呈逐年上升趋势,克拉霉素三年间的敏感率波动较大(P0.05)。结论马鞍山地区男女性患者对抗生素药物的敏感性存在差异,男性患者支原体感染对多种抗生素的敏感率高于女性患者,敏感率较高且稳定的依次为美满霉素、强力霉素及克拉霉素,而女性患者仅对前二者敏感率较高且稳定。
[Abstract]:Objective to investigate the difference and trend of mycoplasma resistance in male and female patients with urogenital tract non-gonococcal infection in Ma'anshan area, and to provide guidance for rational use of antibiotics in clinic. Methods Ureaplasma Urealyticum (UU) and Mycoplasma hominis (MH) culture kit were used to culture and test 2 357 samples from dermatology, urology and obstetrics department of our hospital from 2013 to 2015. SPSS 22.0 software was used for statistical analysis. Results 1 040 cases of mycoplasma were detected in 2 357 samples, the detection rate was 44. 12%. The positive rate of female (837 cases, 56.17%) was significantly higher than that of male (203 cases, 23.41%). The sensitivity rate of minocycline and doxycycline was the highest (95%), followed by clarithromycin (85%). The sensitivity to quinolones was lower than ofloxacin and levofloxacin. The sensitivity of male patients to roxithromycin, clarithromycin, roxithromycin, sparfloxacin, levofloxacin and azithromycin was significantly higher than that of female patients (P0.05). The sensitivity of mycoplasma to roxithromycin, clarithromycin, roxithromycin and azithromycin in male patients increased year by year (P0.05). The sensitivity rate of mycoplasma to roxithromycin and azithromycin increased year by year. Clarithromycin sensitivity rate fluctuated greatly in three years (P0.05). Conclusion there is a difference between male and female patients in sensitivity to antibiotics in Ma'anshan area. The sensitive rate of mycoplasma infection to various antibiotics in male patients is higher than that in female patients, and the sensitive rate is higher and more stable in order of minocycline. Doxycycline and clarithromycin were more sensitive and stable in female patients.
【作者单位】：马鞍山十七冶医院皮肤科;马鞍山市市立医疗集团临床检验中心;马鞍山市人民医院皮肤科;
【分类号】：R446.5;R691.3

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