内分泌治疗联合经尿道前列腺电切术对晚期前列腺癌患者预后的影响

发布时间：2018-07-28 09:22

【摘要】：目的探讨内分泌治疗联合经尿道前列腺电切术(TURP)对晚期前列腺癌患者预后的影响。方法回顾性分析确诊为晚期前列腺癌的148例患者,所有患者均行内分泌治疗加双侧睾丸切除术治疗。其中联合TURP治疗的52例(TURP组),另外96例仅接受内分泌治疗(非TURP组)。6个月后复查前列腺特异抗原(PSA),比较两组患者治疗后国际前列腺症状评分(IPSS)、生活质量评分(QOL)、最大尿流率(Qmax)及血PSA下降情况,比较两组患者1、3、5年生存率及3年后肿瘤控制率和不良反应发生率。结果治疗后6个月,TURP组患者IPSS评分、QOL评分、Qmax及血PSA等指标均显著优于非TURP组(t=-12.536、-3.03、8.653、-13.252,P0.05);TURP组患者在治疗后1、3、5年生存率上均显著高于非TURP组,差异均有统计学意义(χ~2=6.437、8.032、3.948,P0.05);治疗后3年,TURP组患者肿瘤控制率及不良反应发生率均显著优于非TURP组,差异均有统计学意义(χ~2=5.628、4.854,P0.05)。结论内分泌治疗联合TURP可改善晚期前列腺癌患者的临床预后、提高生存率及肿瘤控制率,且无明显不良反应,值得临床上推广使用。
[Abstract]:Objective to investigate the effect of endocrine therapy combined with transurethral resection of prostate (TURP) on the prognosis of advanced prostate cancer. Methods 148 patients with advanced prostate cancer were retrospectively analyzed. All patients were treated with endocrine therapy and bilateral orchiectomy. 52 cases were treated with TURP (TURP group), the other 96 cases received endocrine therapy (non-TURP group). After 6 months, the (PSA), of prostate specific antigen was compared between the two groups. (IPSS), quality of life score (QOL),) of the two groups after treatment was the highest. Large urine flow rate (Qmax) and blood PSA decreased. The 3-year and 5-year survival rates, tumor control rates and adverse reactions were compared between the two groups. Results six months after treatment, the IPSS scores, QOL scores, Qmax and blood PSA in the TURP group were significantly higher than those in the non-TURP group (t ~ (-12.536) -3.03 ~ 8.653 ~ (-13.252) P 0.05), and the survival rate of 1 and 5 years in the TURP group was significantly higher than that in the non-TURP group. The tumor control rate and adverse reaction rate in TURP group 3 years after treatment were significantly higher than that in non-TURP group (蠂 2 + 5.628 卤4.854 P 0.05). Conclusion Endocrine therapy combined with TURP can improve the clinical prognosis, survival rate and tumor control rate of patients with advanced prostate cancer.
【作者单位】：广东医科大学附属医院泌尿外科;
【分类号】：R737.25

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