锥型束CT在前列腺癌调强放疗中的作用

发布时间：2018-07-31 20:18

【摘要】：目的研究千伏级锥型束CT(CBCT)图像引导在前列腺癌调强放疗(IMRT)中的作用。方法收集接受IMRT的前列腺癌患者67例,其中35例接受无图像引导IMRT,32例接受治疗前的CBCT扫描的图像引导调强放疗(IG-IMRT)。观察图像引导对前列腺癌线性摆位误差的影响,比较两组患者的放疗不良反应有无差别。结果 IG-IMRT组患者x、y、z三维方向线性摆位误差校正前后分别为(2.4±1.8)mm、(4.5±2.0)mm、(3.3±1.2)mm;(0.4±0.6)mm、(0.3±0.7)mm、(0.5±0.4)mm(P0.05)。IMRT组患者与IG-IMRT组患者的2、3级急性尿道反应发生率分别为28.6%、12.5%和5.7%、3.1%;2、3级晚期尿道反应发生率分别为17.1%、9.4%和2.9%、0;2、3级直肠急性反应发生率分别为31.5%、15.6%和11.4%、6.3%;2、3级直肠晚期反应发生率分别14.4%、3.1%和2.9%、0。结论 IMRT可以有效提高前列腺癌患者治疗的准确性,降低患者的放疗不良反应,提高前列腺癌患者的生活质量。
[Abstract]:Objective to study the role of KV cone-beam CT (CBCT) image guidance in (IMRT) of prostate cancer. Methods Sixty-seven patients with prostate cancer received IMRT, of which 35 received image-guided intensity modulated radiotherapy (IG-IMRT) with CBCT scan before treatment. To observe the effect of image guidance on linear pendulum error of prostate cancer and compare the difference of adverse reaction of radiotherapy between the two groups. Results before and after the correction of the linear pendulum error in the three dimensional direction of the IG-IMRT group, it was (2.4 卤1.8) mm, (4.5 卤2.0) mm, (3.3 卤1.2) mm; (0.4 卤0.6) mm, (0.3 卤0.7) mm, (0.5 卤0.4) mm (P0.05). The incidence of acute urethral reaction in the IMRT group and IG-IMRT group was 28.62.5% and 5.73.1.1% respectively. The incidence of acute bowel reaction was 31. 5% and 11. 4%, respectively. The incidence of late rectal reaction was 14. 4% and 2. 9% respectively. Conclusion IMRT can effectively improve the accuracy of treatment of prostate cancer, reduce the adverse reaction of radiotherapy, and improve the quality of life of patients with prostate cancer.
【作者单位】：天津医科大学肿瘤医院国家肿瘤临床医学研究中心天津市肿瘤防治重点实验室天津市恶型肿瘤临床研究中心放射治疗科;
【分类号】：R737.25

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