PKRP与TURP治疗良性前列腺增生的Meta分析

发布时间：2018-08-03 21:59

【摘要】：目的：[A2]系统评价经尿道双极等离子前列腺电切术（transuretheral plasmakineticresection of prostate, PKRP）与经尿道前列腺电切术(transurethral resection ofprostate，TURP）两种手术方式治疗良性前列腺增生的临床综合评价。包括在手术时间、手术出血量、导尿管留置时间、术后膀胱冲洗时间、术后住院时间等治疗效果方面及IPSS、Qmax、QOL评分、RUV有效性指标方面的差异情况。方法：采用电子检索和手工检索对文献进行初检,电子检索数据库包含有相关期刊论文、CENTRAL、Medline database、Cochrane图书馆和中国循证医学/Cochrane中心数据库(CEBM\CCD)等数据库,检索所有有关PKRP和TURP治疗良性前列腺增生症的随机对照试验（RCT），检索时间均为建库至2014年1月31日。手工检索《中华泌尿外科学杂志》等3种杂志，纳入采用涉及经尿道双极等离子切除术（transuretheral plasmakinetic resection of prostate, PKRP）与经尿道前列腺电切术(transurethral resection of prostate，TURP）随机对照试验(RCT),数据由两名研究员各自独立提取,纳入研究的方法学质量采用Jadad质量评分标准,运用Cochrane协作网提供的专用Meta分析软件RevMan5.2对统计数据进行分析。结果初检中文文献564篇,外文文献64篇,最终纳入15篇RCT(其中4篇英文,11篇中文)涉及对照统计。Meta分析结果显示,PKRP组在手术时间（min）、术中失血量（mL）、术后持续膀胱冲洗时间（d）和留置导尿时间（d）、术后住院时间（d）、国际前列腺症状评分（IPSS）、最大尿流率（Qmax）等方面好于TURP组，疗效差异有统计学意义；在术后半年残余尿量（RUV）和生活质量指数（QOL）等方面没有明显差异没有统计学意义。结论[A3] PKRP与TURP治疗良性前列腺增生相比，在手术时间、手术出血量、导尿管留置时间、术后膀胱冲洗时间、术后住院时间、IPSS评分、Qmax等治疗效果方面较好,在术后半年IPSS评分，，QOL评分、Qmax、RUV等有效性方面没有显著性差别。
[Abstract]:Objective: [A2] to evaluate the treatment of benign prostatic hyperplasia (BPH) by transurethral bipolar plasma prostatectomy (transuretheral plasmakineticresection of prostate, PKRP) and transurethral resection of prostate (transurethral resection of prostate TURP). The differences were included in the time of operation, the amount of bleeding, the time of catheter indwelling, the time of bladder irrigation after operation, the time of hospitalization after operation, and the effective index of RUV in IPSS QmaxQOL score. Methods: the literature was first checked by electronic retrieval and manual retrieval. The electronic retrieval database included the Chinese Journal Full-text Database (CENTRAL) Medline database and the CEBM\ CCD database of evidence-based medicine in China. All the randomized controlled trials of PKRP and TURP for the treatment of benign prostatic hyperplasia (BPH) were searched. The search time of (RCT), was built up to January 31, 2014. To retrieve by hand the Chinese Journal of Urology and surgery, etc. (RCT), data from randomized controlled trials involving transurethral bipolar plasma resection (transuretheral plasmakinetic resection of prostate, PKRP) and transurethral resection of the prostate (TURP) were independently extracted by two researchers. The quality of methodology included in the study is based on the Jadad quality scoring standard, and the statistical data are analyzed by RevMan5.2, a special Meta analysis software provided by the Cochrane Cooperative Network. Results 564 Chinese and 64 foreign literatures were first examined. The results of Meta-analysis showed that the blood loss during (min), operation, continuous bladder irrigation time (d) after (mL), and hospitalization time after (d), in (min), group were included in 15 RCT articles (4 articles in English and 11 articles in Chinese). The results of Meta-analysis showed that the blood loss during (min), operation and the duration of continuous bladder irrigation after (mL), and the time of hospitalization after (d), of indwelling catheterization. The (d), International Prostate symptom score (IPSS),) was better than the TURP group in terms of maximum urinary flow rate (Qmax). There was no significant difference in residual urine volume (RUV) and quality of life index (QOL). Conclusion [A3] PKRP is more effective than TURP in the treatment of benign prostatic hyperplasia (BPH), such as operation time, blood loss, catheter indwelling time, postoperative bladder irrigation time, postoperative hospitalization time and Qmax, etc. There was no significant difference in the effectiveness of IPSS scores and Qmaxl scores in half a year after operation.
【学位授予单位】：南华大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R699.8

【参考文献】