血液净化治疗联合济生肾气丸对尿毒症患者蛋白质和能量贮备的影响

发布时间：2018-08-05 13:09

【摘要】：目的:探讨血液净化治疗联合济生肾气丸对尿毒症患者蛋白质和能量贮备的影响。方法:124例尿毒症患者随机分为对照组(n=60)和试验组(n=64)。对照组患者给予血液净化治疗,250~300 ml/min,每次4 h,每周3次;试验组患者在对照组治疗的基础上给予济生肾气丸9 g,每日2次。两组疗程均为12个月。观察两组患者治疗前后血红蛋白(Hb)、血尿素氮(BUN)、丙氨酸转氨酶(ALT)、白蛋白(ALB)、血清转铁蛋白(TF)和血浆纤维连接蛋白(FN),收缩压、舒张压和平均动脉压,体质量指数(BMI)、皮下脂肪厚度和上臂肌肉周径等情况。结果:治疗后,两组患者Hb、TF、FN水平均显著高于治疗前,且试验组高于对照组;ALT、ALB、BUN水平和收缩压、舒张压、平均动脉压均显著低于治疗前,且试验组低于对照组;对照组患者BMI、皮下脂肪厚度和上臂肌肉周径均显著低于治疗前和试验组,差异均有统计学意义(P0.05);试验组患者BMI、皮下脂肪厚度和上臂肌肉周径与治疗前比较,差异均无统计学意义(P0.05)。结论:在血液净化治疗的基础上给予济生肾气丸可改善患者体内微环境,提高机体免疫功能,降低炎症引起的代谢加快,改善患者蛋白质和能量贮备,有助于提高其生存质量。
[Abstract]:Objective: to investigate the effect of blood purification therapy combined with Jisheng Shenqi pills on protein and energy storage in uremic patients. Methods 124 patients with uremia were randomly divided into control group (n = 60) and experimental group (n = 64). The patients in the control group were treated with blood purification therapy of 250 ml / min for 4 h, 3 times a week, and the patients in the experimental group were given 9 g of Jisheng Shenqi pills on the basis of the treatment in the control group, twice a day. The course of treatment was 12 months in both groups. Serum transferrin (TF) and plasma fibronectin (FN), systolic blood pressure, diastolic blood pressure and mean arterial pressure were observed before and after treatment with hemoglobin (Hb), blood urea nitrogen, (BUN), alanine aminotransferase, (ALT), albumin (ALB), and plasma fibronectin (FN),. Body mass index (BMI),) subcutaneous fat thickness and upper arm muscle circumference. Results: after treatment, the levels of HbtbtfN in both groups were significantly higher than those before treatment, and the levels of ALB bun, systolic blood pressure, diastolic blood pressure and mean arterial pressure in the experimental group were significantly lower than those in the control group, and those in the experimental group were lower than those in the control group. The BMI, subcutaneous fat thickness and muscle circumference of upper arm in control group were significantly lower than those before treatment and experimental group (P0.05), the BMI, thickness of subcutaneous fat and circumference of upper arm muscle in test group were significantly lower than those before treatment (P0.05). The difference was not statistically significant (P0.05). Conclusion: on the basis of blood purification therapy, Jisheng Shenqi pills can improve the microenvironment, improve the immune function, decrease the metabolism caused by inflammation, improve the protein and energy storage, and improve the quality of life.
【作者单位】：上海市奉贤区中心医院急诊科;
【分类号】：R692.5

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